Overview
Job description
Principal Scientist, Mitochondrial & Cellular Toxicity. This role will apply laboratory technical support and specialist advanced cellular modelling approaches to generate data to elucidate mechanisms of toxicity, understand species differences, identify novel translational safety biomarkers, and inform project decisions. The Scientist will conduct paper- and laboratory-based studies in support of predictive, mechanistic, and translational toxicological investigations across new drug modalities (oligos, ADC, T-Cell Engagers, etc.) for projects in discovery and development. The role requires on-site presence at GSK Stevenage. The position is agreed to be at G8 level but may be considered at G7 for exceptional candidates.
In this role you will
* Design and execute innovative investigative toxicology experiments or technical work programs to support Project Issues with limited supervision; responsibilities include study planning, experiment organization, sample preparation, data generation, processing, analysis and reporting.
* Plan next steps based on interpretation of results in collaboration with the Investigative Lead.
* Contribute to the establishment and maintenance of a scientifically current, state-of-the-art laboratory environment.
* Lead development of new cellular assay formats/techniques (from tissues, primary cells, or cell culture systems) for investigating mechanisms and translating organ and cellular toxicities and safety risks to the clinic, including routine mammalian cell screening assays.
* Provide high quality data with data integrity (DI) and quality control (QC) of study data.
* Be a subject matter expert in the field with theoretical and technical understanding; provide expert advice to Project Teams, advisory Safety Panels, Target Safety Reviews and external partners as required.
* Understand the disease target under investigation and, if applicable, the therapeutic area and programme/project plan and potential safety issues of assigned studies.
* Collaborate across study teams to optimize efficiency and quality to meet project goals and timelines.
* Prepare detailed oral or written reports and interim summaries within agreed timelines.
* Ensure clear, concise, timely communication and provide accurate information to study/report tracking systems.
* May take a leadership role for enabling functions such as safety, facilities, compliance or data integrity on behalf of the group.
* Participate in collaborations with internal and external partners to develop and deploy new approaches to improve efficiency, prediction, mechanistic understanding, and translation of drug safety risks.
* Ensure compliance with GSK SOPs and Policies, GLP, data integrity, safety, and animal welfare guidelines.
Why you?
Basic Qualifications & Skills:
We are looking for professionals with these required skills to achieve our goals:
* MSc or PhD or equivalent by experience in Molecular biology, Cellular biology, Toxicology and/or related biology science.
* Experience with cellular biology using advanced cellular systems and investigative safety/toxicology studies; ideally within a pharmaceutical or research institute setting; subject matter expert for a specific technical area (e.g., certain types of in vitro cellular models, or organ toxicity such as liver, kidney, bone marrow).
* Significant knowledge of and proficiency in routine and advanced cellular techniques and interpretation of data for risk assessment.
* Experience providing technical subject matter expertise to Project Teams, Safety Project Specialists, and other stakeholders, including integrated assessments of pre-clinical toxicity data.
* Understanding of modelling platform applications to support adverse outcome pathways and translation from non-clinical species to humans across various modalities.
* Proficiency in laboratory and in silico techniques to build and implement new human-relevant cell models or other assays to meet project needs, with focus on large molecules.
* Excellent written and verbal communication and organizational skills, ideally with relevant publication record.
* Ability to work across boundaries as part of cross-functional matrix teams, including authorship and presentation of scientific content.
* Familiar with platform data and bioinformatics software and collaborating with data analysts to leverage high-content data approaches to support mechanistic toxicology studies and risk assessment.
Closing Date for Applications 12th of November, 2025 (COB)
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying, please use the cover letter or CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information provided will be used to assess your application.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants receive equal consideration without regard to race, color, religion, sex, pregnancy, gender identity, sexual orientation, parental status, national origin, age, disability, genetic information, military service or any basis prohibited by law.
We believe in an agile working culture. If flexibility is important, please discuss opportunities with the hiring team.
Adjustments: should you require any adjustments to our process, contact UKRecruitment.Adjustments@gsk.com or 0808 234 4391. The helpline is available 8.30am to 12.00 noon Monday to Friday. If your enquiry does not relate to adjustments, please refer to the UK Recruitment FAQ guide via the Careers section.
Important notices
GSK does not accept referrals from employment businesses/agencies without prior written authorization. Some US reporting requirements may apply for healthcare professionals; more information is available through the CMS Open Payments data.
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