Direct message the job poster from Leal Therapeutics
VP of Analytical Science and Development
Position: Senior Bioanalytical Scientist (title commensurate with experience)
Leal Therapeutics is seeking a highly driven senior level bioanalytical scientist to join its Analytical Science and Development team. This role will have a large impact in a growing company with programs ranging from discovery to clinical development. The Senior Bioanalytical Scientist is expected to conduct and manage bioanalytical projects for PK and PD characterization of drug candidates in various modalities including small molecules, oligonucleotides, and antibody-oligonucleotides conjugates (AOCs).
About Leal Therapeutics:
* Clinical-stage biotechnology company developing novel, precision therapeutics for major diseases of the central nervous system (CNS) with critical unmet needs including Schizophrenia and ALS.
* Core operations in Worcester, MA and Newton, MA
* Fast-paced startup environment with broad exposure to multiple facets of biotechnology and drug development
* Emphasis on cross-functional collaboration within a collegial, learning-oriented environment
* Ability to have a large impact in a rapidly growing company
Key Responsibilities:
* Develop, optimize, and perform extraction and quantitative analysis of drug candidates (small molecules, oligonucleotides, and AOCs) in biomatrix with various technologies including but not limited to liquid chromatography (LC), mass spectrometry (MS), ligand binding assay (LBA), biochemistry, and capillary electrophoresis (CE)
* Develop, optimize, and perform appropriate bioanalytical methods to quantify pharmacodynamic and disease-relevant biomarkers (e.g., proteins, lipids, amino acids) to support mechanism of action, efficacy, and safety assessments in preclinical and clinical studies
* Oversee CRO partnerships for method development, validation (GLP/non-GLP), sample analysis, and troubleshooting, ensuring data quality and timely deliverables from discovery to clinical development
* Ensure bioanalytical methods are fit-for-purpose and meet regulatory expectations
* Collaborate with preclinical pharmacology, DMPK, clinical development, and CMC teams to align bioanalytical plans to ensure timely delivery of PK and PD biomarker results
* Document all work in electronic lab notebook
* Organize and maintain bioanalytical lab space and ensure function of equipment for appropriate sample storage, preparation and analysis
* Communicate study results in forms of reports, presentations, and conference posters or talks
* Adhere to all company environmental, health and safety policies
Education, Experience, and Qualities Required:
* BS or MS in relevant scientific disciplines with 3-10 years of working experience
* Method development and validation experience in quantitation of small molecule, oligonucleotides, or protein/peptide in various tissue types is required
* Method development and validation experience in liquid chromatography and mass spectrometry is required
* Method development and validation experience in LBA, CE, or biochemistry assay is desired
* Experience in bioanalytical testing under GLP regulation is desired
* Strong organizational skillset with ability to manage multiple concurrent workstreams
* Excellent verbal and written communication skills
* Ability to work collaboratively in a fast-paced, dynamic environment
* Passion for bringing new therapies to serve patients with unmet medical needs
If interested, please contact Hong Jiang, VP of Analytical Science and Development (hong.jiang@lealtx.com) and Human Resources ( humanresources@lealtx.com) with a brief statement of interest and resume.
Leal is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national orientation, veteran, or disability status.
Seniority level
* Seniority level
Mid-Senior level
Employment type
* Employment type
Full-time
Job function
* Job function
Research, Analyst, and Information Technology
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