Grade UE07 - £39,347 - £46,974 per annum
College of Medicine and Veterinary Medicine - MRC - Human Genetics Unit
Full time - 35 hours per week
Fixed term contract - 24 months
The Opportunity:
A postdoctoral researcher is sought for an initial 24-month post in Professor Yanick Crow's group to investigate links between genomic DNA and interferon-mediated innate immune signalling.
The primary viral DNA sensor cGAS is present in the nucleus, begging the question as to how the immunogenicity of self-nuclear DNA is regulated. Related to this observation, in 2020, we described mutations in the replication-dependent histone pre-mRNA processing complex to result in enhanced cGAS–STING mediated interferon signalling through a disturbance of linker histone protein stoichiometry (Nat Genet, 2020, 52, 1364-72). More recently, in unpublished data, we have identified mutations in a chromatin remodeller to also lead to cGAS-dependent interferon induction. Notably, these mutations are associated with significant neurological disease.
In line with these observations, this new role will focus on the link between nuclear DNA/chromatin and interferon signalling in iPSC-derived neurological cell types.
Applicants with expertise in iPSC technology, chromatin biology and innate immunity are particularly encouraged to apply.
The Crow laboratory is multidisciplinary, dynamic and international, with sustained high-quality productivity. Our work is generously supported by funding from the Medical Research Council, and an ERC Advanced Grant to the PI. Expertise in the group extends across molecular genetics, cell biology, model organisms and computational approaches. For further details on our group: https://www.ed.ac.uk/mrc-human-genetics-unit/research/crow-research-group
Informal enquiries to: Yanick.crow@ed.ac.uk
The post is available from 1st June 2024.This post is full-time (35 hours per week),
Your skills and attributes for success:
* PhD in molecular genetics/biology or a closely related subject
* Expertise in chromatin biology and/or innate immune signalling
* Specific skills relating to the following techniques: mammalian cell/tissue culture, cloning and transfection, gene silencing and editing (CRISPR), transcriptomic profiling, western blotting, iPSC/neuronal cell culture and experimentation, CUT&TAG/CUT&RUN, immunoprecipitation, mass spectrometry
* Ability to apply relevant knowledge, skills and techniques in research
* Excellent knowledge of scientific English for speaking, reading, and writing
Click to view a copy of the full job description
As a valued member of our team you can expect:
* A competitive salary of £39,347 - £46,974 per annum
* An exciting, positive, creative, challenging and rewarding place to work.
* To be part of a diverse and vibrant international community
* Comprehensive Staff Benefits, such as a generous holiday entitlement, a defined benefits pension scheme, staff discounts, family-friendly initiatives, and flexible work options. Check out the full list on our staff benefits page(opens in a new tab) and use our reward calculator to discover the total value of your pay and benefits
Championing equality, diversity and inclusion
The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.
Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our right to work webpages(opens new browser tab).
The University is able to sponsor the employment of international workers in this role. If successful, an international applicant requiring sponsorship to work in the UK will need to satisfy the UK Home Office’s English Language requirements and apply for and secure a Skilled Worker Visa.
Key dates to note
The closing date for applications is 28 May 2024.
Unless stated otherwise the closing time for applications is 11:59pm GMT. If you are applying outside the UK the closing time on our adverts automatically adjusts to your browsers local time zone.
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