A leading biotech organisation is seeking a Senior Scientist with DMPK expertise to support oncology-focused discovery programs. You will develop fit-for-purpose DMPK strategies, generate and interpret ADME/PK data, and work closely with internal project teams and external CRO partners to drive decision‑making across project stages.
Key Responsibilities
* Develop and evolve an appropriate DMPK screening cascade aligned to project stage and objectives.
* Design, execute and interpret in vitro ADME assays, communicating results clearly to project team members.
* Oversee CRO activities including compound submissions, experiment tracking, and timely communication of data updates.
* Prepare and maintain slide decks and documentation summarising CRO outputs and project progress; manage purchase orders and invoicing related to CRO work.
* Maintain accurate, complete and up-to-date electronic laboratory notebooks in line with internal standards.
* Perform LC–MS/MS analyses for small and large molecules, including routine maintenance and basic troubleshooting.
Key Requirements
* PhD or BSc/MSc with relevant experience in a life sciences discipline, plus industrial drug discovery experience.
* Practical knowledge of in vitro ADME assays including microsomal stability, hepatocyte stability, protein binding and permeability.
* Experience using Phoenix WinNonlin.
* Knowledge and prior experience of metabolite identification.
* Strong time management, excellent written and verbal communication skills, and the ability to build effective relationships with internal and external partners.
* Experience advancing discovery programs from Lead Optimisation (LO) through candidate selection.
* Knowledge of PK–PD and/or PBPK modelling and human dose prediction.
* Practical experience in bioanalysis by LC–MS/MS.
* Experience with MassLynx and/or UNIFI.
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