CK Group are recruiting for an experienced and dynamic Scientist, at either Senior/ Principal level, to join an early-stage biotechnology start-up, based in Oxford, on a permanent basis. The Company: Our client is an early-stage biotechnology start up, combining artificial intelligence (AI), and advanced high-throughput TCR screening techniques to revolutionise the treatment of solid cancers. Location : Oxford The Role: To lead the in vivo and in vitro validation of T-cell engagers, and help drive forward the development of TCR engineering and processes. Responsibilities : To perform high-throughput TCR display methods by purifying recombinant TCRs. Carry out protein characterisation (expression, purification and biophysical analysis). Design and characterise TCRs for disease targets. Oversee lab protocols and technical documents. To be hands-on in the lab and manage tissue culture preparations. Skills in data analysis (using software R) for Next Gen Sequencing analysis - desirable. Your Background: PhD qualified (biochemistry, immunology, cell biology) plus strong laboratory experience (academia and industry). Experience in in vivo and in vitro validation of T-cell engagers (TCEs). Experience in Investigational New Drug (IND-enabling/ approval) - ESSENTIAL. Expertise in cell and immunological assays (flow cytometry, ELISA) with knowledge around cloning and PCR. Strong background in protein characterisation and biophysical characterisation. Benefits : Competitive salary, option for home working (as per project demands), stock options Apply: It is essential that applicants hold entitlement to work in the UK. Please quote job reference 141 244 in all correspondence. If this position isn't suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news.