Principal Scientist, Mitochondrial & Cellular Toxicity
Location: UK – Hertfordshire – Stevenage
This role will be accountable for the application of laboratory technical support and specialist advanced cellular modelling approaches to generate data to elucidate mechanisms of toxicity, understand species differences, identify novel translational safety biomarkers, and inform project decisions. With knowledge and experience of cell culture and advanced cellular models (e.g. Complex In Vitro Models, Human Model Systems, Micro Physiological Systems, and/or Organ on Chip models), the Principal Scientist will conduct laboratory-based studies in support of predictive, mechanistic, and translational toxicological investigations across new drug modalities (Oligos, ADC, T‑Cell Engagers, etc.) for projects in discovery and development. The position is lab‑based and requires a regular on‑site presence at GSK Stevenage.
Responsibilities
* Design and execute innovative investigative toxicology experiments or technical work programs to support Project Issues with limited supervision; work includes study planning, experiment organization, sample preparation, data generation, processing, analysis and reporting.
* Plan next steps based on interpretation of results in collaboration with the Investigative Lead.
* Contribute to establishment and maintenance of a scientifically current, state‑of‑the‑art laboratory environment.
* Lead development of new cellular assay formats/techniques for the investigation of mechanisms and translation of organ and cellular toxicities and safety risks to the clinic.
* Provide high quality data acceptable to appropriate principles of data integrity, including quality control of study data.
* Be a subject matter expert in your field and provide expert advice to Project Teams, advisory Safety Panels, Target Safety Reviews and external partners as required.
* Understand the disease target, therapeutic area and safety issues of assigned projects or studies.
* Collaborate across areas to optimise study efficiency and quality to meet project goals and timelines.
* Prepare detailed oral or written reports and interim summaries within agreed timelines.
* Ensure clear, concise timely communication, and provide accurate information to study/report tracking systems.
* May take a leadership role for specific enabling functions such as safety, facilities, compliance or data integrity on behalf of the group.
* Participate in collaborations to assist development and deployment of new approaches to improve the efficiency, prediction, mechanistic understanding, and translation of drug safety risks.
* Ensure compliance with GSK SOPs and Policies, GLP, and data integrity, safety, and animal welfare guidelines.
Qualifications
* MSc or PhD in Molecular biology, Cellular biology, Toxicology and/or related biological science.
* Experience with advanced cellular systems and investigative safety/toxicology studies, ideally within a Pharmaceutical or Research Institute setting.
* Significant knowledge and proficiency in routine and advanced cellular techniques and data interpretation for risk assessment.
* Experience providing technical subject matter expertise to Project Teams and Safety Project Specialists.
* Understanding of modelling platform applications supporting adverse outcome pathways and translation from non‑clinical species to humans.
* Proficiency in building and implementing new human relevant cell models or assays to fill strategic gaps.
* Excellent written and verbal communication and organisational skills, with evidence of a relevant publication record.
* Ability to work across boundaries as part of cross‑functional matrix teams.
* Familiarity with platform data and bioinformatics software and collaborating with analysts/bioinformaticians.
Benefits and Working Conditions
* Competitive salary, annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.
* Hybrid working model empowering a balance between remote and in‑office work.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any basis prohibited under federal, state or local law.
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