This job is with AstraZeneca, an inclusive employer and a member of myGwork – the largest global platform for the LGBTQ+ business community. Please do not contact the recruiter directly.
Location: Cambridge, UK
Salary: Competitive with excellent benefits!
Introduction to role: Are you a Scientist with a well founded in vitro assay development experience who wants to add large pharma industry experience to your portfolio? Are you fueled by the commitment to help patients and see what science can do? An opportunity has arisen to be a part of the Bioassay, Biosafety and Impurities Group (BB&I) accountable for developing state‑of‑the‑art methods to evaluate product quality by measuring biological activity and detecting, characterizing, and quantifying product variants and process‑related impurities for biologics (e.g. antibodies and antibody‑like molecules). This enables product understanding, manufacturing process development, formulation, drug product development, and regulatory filings to bring our drugs to the clinic and eventually onto the market. The group also oversees control systems, including specifications, comparability, and shelf‑life strategies required by regulatory agencies, performs technical transfer of methods to clinical quality control and commercial launch sites, and provides technical support and lifecycle management post‑launch.
Our Expectations
* Use your knowledge of cell culture and hands‑on potency assay development in a team‑oriented environment.
* Support our drug development programmes with data, effectively utilising existing and novel technologies and instrumentation.
* Convert opportunities and resources to succeed and thrive around the team and communicate achievements to different audiences, including team meetings, global group meetings and matrix teams.
* Learn from experience and guidelines/documentation to increase responsibilities and complexity of tasks performed with a higher level of autonomy.
* Motivated by curiosity and a solid scientific foundation to learn and train others in utilising new technologies and automation‑friendly approaches.
* Build on AZ's science‑driven dynamic environment.
Accountabilities
* Develop biochemical and cell‑based potency assays based on drug mode of action and carry out routine sample testing for large molecules in AZ's pipeline in a timely fashion.
* Enable transfer of any methods to other groups as appropriate.
* Accurately record all data clearly and concisely with a clear understanding of its implications within the overall context of drug development.
* Manage own work to ensure that agreed targets are met and to agreed quality standards, communicating progress appropriately.
* Discuss and defend experimental findings at cross‑functional meetings, representing the Bioassay, Biosafety and Impurities Group in CMC teams, present at internal symposia and external conferences.
* Prepare for review clear and concise technical documents like SOPs, work plans, work reports and instructional documents.
* Work alongside team members/automation engineers to bridge manual experimental and data analysis protocols into structured, automation‑ready workflows.
* Assist in the training & coaching of others in procedures and practices.
* Ensure that work is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards.
Essential Skills
* For Senior Scientist – PhD with +2‑6 yrs of experience (or equivalent relevant scientific experience).
* For Scientist – MSc with +2‑6 yrs experience (or equivalent relevant scientific experience).
* Thorough understanding of immunoassay/binding assays.
* Thorough understanding of mammalian cell culture and hands‑on experience with in‑vitro cell‑based assay techniques and their applications e.g. cellular signalling, receptor binding assays, reporter assays, proliferation assays, cytotoxicity, ELISA, MSD, HTRF, AlphaLISA, SPR, imaging assays and flow cytometry.
Desired Skills
* Drug development experience in academia, Pharma/Biotech industry.
* Experience with ADCC/CDC/ADCP assays and Bioassay/CMC.
* Experience with cell line generation and molecular biology techniques.
* Experience with liquid handlers e.g Integra Assist, Dragonfly, Hamilton, etc.
* Experience with data analysis software's like GraphPad Prism, JMP, SoftMax Pro, etc.
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