Overview:
While professional experience and qualifications are key for this role, make sure to check you have the preferable soft skills before applying if required.
We are seeking an exceptional Scientist with a passion for immuno-oncology and hands-on expertise in CAR-T and TCR cell therapy discovery and development. This is a dynamic, lab-based role based at our Oxford site, where you will lead experimental design, execute in vitro functional assays, and collaborate cross-functionally to advance innovative cell therapies toward the clinic.
This position offers an exciting opportunity to contribute directly to the design and optimisation of novel CAR-T constructs within a fast-paced, collaborative biotech environment.
Key Responsibilities:
* Lead the design, development, and execution of in vitro functional assays to evaluate CAR-T/TCR activity, including cytotoxicity, cytokine release, and target engagement.
* Develop, optimise, and troubleshoot protocols for CAR construct screening and primary T cell engineering.
* Design and perform multiparameter flow cytometry experiments; analyse and interpret complex immunophenotyping data.
* Develop and validate ELISA and Western blot assays to support functional and mechanistic studies.
* Generate actionable insights from experimental data to guide CAR/TCR construct selection and refinement.
* Collaborate closely with bioinformatics, translational, and cell engineering teams to integrate data and align project goals.
* Prepare scientific presentations, technical reports, and contribute to regulatory documentation as needed.
* Stay abreast of emerging trends in CAR-T/TCR research and immuno-oncology; implement innovative approaches in R&D.
* Mentor junior scientists and foster a culture of scientific rigor, curiosity, and innovation.
Qualifications:
* PhD in Immunology, Molecular Biology, Cell Biology, or related discipline is required for Scientist level
* Hands-on expertise in CAR-T/TCR development, T cell engineering, or immune cell therapy.
* Strong practical knowledge of multiparameter flow cytometry, ELISA, Western blot, assay development, and primary immune cell culture.
* Proven ability to analyse complex datasets and extract meaningful biological insights.
* Excellent scientific communication skills, both written and verbal.
* Ability to work independently and collaboratively in a fast-paced, team-oriented environment.
* Must be able to work on-site at our Oxford facility.
Why Join Us?
* Contribute to groundbreaking advances in next-generation cell therapy innovation.
* Work within a mission-driven, supportive, and collaborative scientific team.
* Opportunity to make a tangible impact on the future of immuno-oncology therapies.
If you are passionate about driving CAR-T/TCR therapy development and thrive in a fast-moving, impactful environment, and are able to work at our Oxford site, we encourage you to apply.