Overview :
Entourage Diagnostics is a pioneering company revolutionizing health diagnostics and our understanding of longevity. We harness breakthrough proteomics technology and AI-powered diagnostics to uncover what's truly happening inside the human body. This innovative approach allows us to analyze thousands of protein biomarkers, aiming to discover what's truly happening inside the body long before symptoms emerge. Our commitment is to set a new standard for precision and depth in health diagnostics, with a vision to deliver tens and hundreds of thousands of biomarkers in the coming years.
As a spin-out from the University of Glasgow, Entourage Diagnostics has secured funding and is rapidly expanding its capabilities. We are actively seeking a visionary Mass Spectrometrist / Proteomics Scientist to drive our biomarker discovery and validation projects. This pivotal role will involve developing innovative proteomic workflows using advanced mass spectrometry systems and acquisition techniques like DIA and PRM. The successful candidate will be instrumental in ensuring the seamless operation and data integrity of biofluid proteomics experiments through robust maintenance and troubleshooting of instruments. This is an exciting opportunity to contribute to cutting-edge research in a collaborative environment with access to state-of-the-art instrumentation and advanced proteomics technologies.
Position is on-site at the West of Scotland Science Park.
Key Responsibilities :
* Design and execute robust proteomics experiments aimed at identifying and validating biomarkers.
* Develop and refine workflows using advanced techniques such as DIA and PRM on Thermo Tribrid systems.
* Integrate automated protocols, including liquid handling systems, to enhance experimental throughput.
* Oversee the routine maintenance and performance optimization of MS instruments.
* Diagnose and resolve technical issues, ensuring minimal downtime and consistent data quality.
* Analyze complex proteomic datasets using software tools including Skyline, FragPipe, and Proteome Discoverer.
* Compile, interpret, and present data findings to guide the biomarker development strategy and support decision-making.
* Work closely with interdisciplinary teams—biologists, chemists, and data scientists—to translate experimental results into actionable insights.
* Contribute to the preparation of technical reports, publications, and presentations highlighting research outcomes.
Essential Criteria :
* PhD or Master’s in Analytical Chemistry, Biochemistry, Molecular Biology, or a related field with a focus on proteomics.
* Demonstrated hands-on experience with Orbitrap mass spectrometry systems.
* Proficient in advanced data acquisition techniques (DIA and PRM)
* Proven expertise in the maintenance, troubleshooting, and overall management of MS instrumentation.
* Familiarity with data analysis platforms such as Skyline, FragPipe, and Proteome Discoverer.
* Excellent problem-solving abilities and keen attention to detail.
* Strong communication skills with a proven ability to work in collaborative, interdisciplinary teams.
* Ability to manage multiple projects concurrently and meet deadlines in a dynamic research environment.
Desirable Criteria :
* Expertise profiling complex matrices such as plasma, serum or CSF, from depletion/enrichment through LC-MS/MS analysis.
* Hands-on experience designing, executing and interpreting isobaric-tag workflows,
* Experience with laboratory automation and liquid handling systems.
* Strong coding skills to build, validate and deploy reproducible pipelines for statistical analysis, data quality control and automated reporting.
What We Offer :
* A collaborative work environment dedicated to pioneering biomarker research.
* Access to state-of-the-art instrumentation and advanced proteomics technologies.
* Opportunities for professional growth and career advancement in a spin-out company.
* Competitive salary and comprehensive benefits in a diverse and inclusive work culture.
How to Apply :
Interested candidates should submit a cover letter, curriculum vitae (CV), and contact details for at least three professional references to careers@entouragediagnostics.com. Please highlight your hands-on experience with Thermo Tribrid systems, expertise in MS instrumentation maintenance and troubleshooting, and your proficiency with DIA/PRM techniques and automation technologies.
Data Protection Notice :
By applying for this position, you acknowledge that Entourage Diagnostics will collect and process your personal data for recruitment purposes. This includes information provided in your application, CV, and during interviews. Your data will be handled in accordance with the UK General Data Protection Regulation (UK GDPR) and will be retained only for as long as necessary for the recruitment process or as required by law.