PhD Studentship: Single‑cell spatial multi‑omics for cancer biology
Supervisor: Dr Guiping Wang
Department/Location: Cancer Research UK Cambridge Institute
Start date: 5th January 2027
Deadline for application: 6th July 2026
Project details
Dr Guiping Wang will be joining the CRUK Cambridge Institute as a Group Leader later this year. In the Wang Group, we develop and apply interdisciplinary technologies that bridge high‑resolution spatial biology and genome‑wide discovery. We integrate multi‑omic sequencing and quantitative imaging to build a multi‑scale understanding of how molecular composition and subcellular organisation shape cell function, plasticity and disease. A central biology focus of the lab is extrachromosomal DNA (ecDNA) - circular DNA elements that drive oncogene amplification, intratumour heterogeneity and therapeutic resistance across many aggressive solid cancers. This PhD project will develop and apply cutting‑edge single‑cell and spatial multi‑omic approaches that link molecular signatures to cancer cell vulnerabilities. Working at the interface of molecular, chemical and optical method development and cancer biology, the student will build tools that connect gene‑regulation mechanisms with cellular phenotypes in cancer cells and use them to dissect how ecDNA is organised, regulated and exploited.
Preferred skills / knowledge
We are looking for a curious, motivated and collaborative student with a strong background at the intersection of molecular biology, genomics, microscopy and computation. Applicants should hold or expect to gain an undergraduate or Master’s degree in biophysics, biology, physics, chemistry, bioengineering, physical chemistry, biomedical sciences, or a related discipline.
Funding and benefits
This four‑year studentship is funded by Cancer Research UK Cambridge Institute. It includes full funding for University fees and an index‑linked stipend starting at £22,500 for the four years (2026‑27).
Eligibility
Applications are welcomed from both UK and overseas students, including recent graduates or final‑year undergraduates who hold or expect to gain a First / Upper Second Class degree (or equivalent) from any recognised university worldwide. Research experience gained during a Master’s study or in a laboratory is strongly encouraged.
Equal opportunity statement
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
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