The Role
The Rosalind Franklin Institute (the Franklin) is a technology institute for life science, creating innovative technologies that transform our understanding of life. Our technologies, borne out of innovation in physical sciences, create collaborations and new avenues in life science which will lead to new therapeutics and advance our understanding of human biology.
We are seeking a highly motivated and experienced biophysicist/computational chemist to join our liquid phase electron microscopy team to develop molecular dynamics simulations of cryo-EM and LPEM maps to inform our experimental observations, as part of our Science Challenge on multi-dimensional imaging. Our aim is to develop simulated “movies” of the protein conformational ensemble from time-resolved cryo-EM datasets and use these to better understand the maps produced in liquid phase EM applications. Experience working with computational approaches to protein dynamics is essential, expertise in the application of molecular dynamics to cryo-EM, LPEM or other structural biology methods (X-ray/NMR/Light microscopy etc.) desirable.
As a Research Associate at the Franklin, you will apply your scientific knowledge and skills to our goal of understanding protein dynamics in liquid phase electron microscopy, bringing independent, creative science to our project team. Through this work, you will build scientific independence, develop new science and leadership skills, and establish a growing reputation externally.
Key Responsibilities
As a Research Associate you will:
1. Collaborate closely with an interdisciplinary team of structural biologists and material scientists to achieve scientific objectives.
2. Plan and conduct experiments, analyse and interpret results and supervised delivery of outputs ( research reports, papers, conference abstracts, patent application) in a scientific/technology area of interest.
3. Work within a project team, contributing to wider projects around key Challenges.
4. Lead major contributions to outputs from research including papers, patents and both internal and external presentations.
5. Support and develop others including day-to-day supervision of students or visitors in areas related to your own research.
6. Have supervised, staged progression to first stages of scientific independence with opportunities to further develop science and skills/experience.
7. Enhance your research through collaboration with other researchers and make active contributions to exchanging of ideas through your own network.
8. Be able to understand, interpret, create and communicate appropriately within a research context.
9. Develop search and discovery skills and techniques.
10. Be supervised by a Scientist/Senior Scientist in delivery of research outputs, either in the context of a project or Challenge or as an early career development fellow.