Fixed term, 2 years
Applications are invited for a Postdoctoral Scientist to join Dr. Michael Hastings’ and Dr. John O’Neill’s multidisciplinary research groups, in collaboration with Astrazeneca, to investigate the molecular neurobiology of diet-induced neuroinflammation in the hypothalamus, and its modulation by circadian clock mechanisms.
Modern “western” diets are a major cause of poor health. One of the earliest events is the development of neuroinflammatory responses by glial cells in the hypothalamus, leading to mis-regulation of metabolic homeostasis, which further aggravates disease progression. Cell-autonomous and circuit-based circadian clocks modulate inflammatory and metabolic pathways in health and are in turn disrupted by metabolic disease. Loss of circadian homeostasis again aggravates disease progression. However, the links between clocks and metabolism-induced neuroinflammation are poorly understood both at the molecular and neural network levels. We shall explore the consequences of metabolic disorders at the level of the master mammalian clock, the suprachiasmatic nucleus (SCN) alongside the metabolically relevant centres of the mediobasal hypothalamus (MBH). We shall employ spatial transcriptomics to create a hypothalamic cellular atlas, concentrating on transcriptional responses to various pro-inflammatory metabolic loads and their modulation in circadian time. We shall use ex vivo SCN and MBH organotypic cultures to characterise, compare and contrast the inflammatory and circadian consequences of a simulated high-fat diet. Finally, we shall define causal linkages using intersectional genetics and pharmacology.
Candidates should hold a PhD in a relevant biological subject and be experienced in transcriptome bioinformatics and molecular genetics, including RNA extraction, PCR, DNA cloning, genomic sequence analysis, in situ hybridisation etc. Expertise in hypothalamic neurobiology, including working with in vivo mouse models, metabolic or otherwise, is highly desirable.
LMB has a collaborative working culture and state-of-the-art building on the Cambridge Biomedical Campus. We have on-site parking, cycle enclosures and excellent public transport links to the site. We have a staff restaurant with roof terrace and access to a Campus nursery and sports and social facilities. You will be eligible to join our defined benefit pension scheme, a holiday entitlement of 40.5 days per annum (including bank holidays and privilege days) and a generous employee discount scheme. We are also committed to providing training and development opportunities including support towards role-related qualifications.
The LMB is a world-class research institute within UK Research and Innovation (UKRI). UKRI is nine research councils, working together across all disciplines and sectors. More information can be found at www.ukri.org and www.mrc-lmb.cam.ac.uk.
This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successful applicant is likely to be eligible to apply. Immigration costs (visa and health surcharge) can be reclaimed from UKRI after taking up the post (terms and conditions apply).
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If you are unable to apply online please contact us at recruit@mrc-lmb.cam.ac.uk.
Final appointments will be subject to a pre-employment screening.
We actively support equality, diversity and inclusion in all our activities, processes and culture. We encourage applications from all sections of society. The LMB particularly welcomes women, minority ethnic and disabled candidates to apply for this vacancy as they are currently under-represented. We are a disability inclusive employer and encourage disabled people to apply for this role. You are very welcome to contact us for information about the application process and any adjustments you may require; recruit@mrc-lmb.cam.ac.uk.
£43,391 to £45,589. Starting Salary
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