Position: Senior Scientist or Associate Principal Scientist – Metabolism team – CVRM
Location: Cambridge, UK
Salary: Competitive Salary & Excellent Company Benefits
Main duties and responsibilities
* Develop and validate in vitro, advanced cell models, ex vivo models, and assays for studying obesity and assessing signalling endpoints for multiple target classes.
* Design and perform experiments to evaluate the efficacy and mechanism of novel drug candidates.
* Analyse and interpret experimental data, and present research findings to project teams, external partners and at scientific conferences.
* Collaborate with cross-functional teams to support drug discovery and development projects.
* Stay up to date with the latest scientific advancements in the field of metabolic disease/obesity.
* Identify and develop new target ideas, implement new models/assays and apply latest technologies relevant to obesity and metabolic disease research areas.
* Prepare scientific publications and documents for patents and regulatory submissions.
Essential for the role
* PhD with postdoctoral training in neuroscience, physiology, pharmacology or another relevant field.
* Deep understanding of CNS pathways and signal transduction mechanisms that govern body weight control with a proven track record in the metabolic neuroscience field.
* Demonstrable hands‑on experience working with a variety of in vitro cell‑based and ex‑vivo methods and technologies for researching neurocircuits of appetite regulation.
* Proven ability to develop and optimise new models and protocols, troubleshoot, interpret experimental results/data, and maintain accurate, high‑quality records.
* Proficiency in data analysis and interpretation using relevant software and statistical tools.
* Excellent written and verbal communication skills with an ability to clearly articulate complex scientific concepts, and an ability to quickly learn and embrace new technologies.
* Experience and/or fresh ideas for leveraging AI in obesity research.
* Strong publication record, exemplified by first‑author publications in high‑impact journals.
Desirable requirements
* Experience in leading CNS model development suitable for high‑throughput target screening platforms.
* Experience in molecular biology approaches and vector design for interrogating appetite regulatory pathways and mechanisms.
* HO PIL A/B/C license holder with experience in stereotactic manipulations, analysis of feeding behaviour, and nausea/emesis.
* Experience working in the pharmaceutical industry, particularly in drug discovery and development.
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best.
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