Senior Research Associate in Genetic Epidemiology
We are looking for an enthusiastic and skilled researcher to work on a genetic epidemiology research project investigating whether adiponectin prevents the development of kidney disease, via the glycocalyx that lines the filtering blood vessels in the kidney. This is a 14-month senior research associate post, joining a 3-year post after 22 months completion, working in the Bristol Renal group to undertake a Kidney Research UK funded project.
The project has three main objectives:
* The relationship between circulating adiponectin and measures of glycocalyx depth will be examined
* The causal relationship between circulating adiponectin on diabetic kidney disease (DKD) and chronic kidney disease (CKD) will be explored
* The causal relationship between circulating levels of adiponectin and albuminuria will be explored, and whether circulating matrix metalloproteinases (glycocalyx sheddases) mediate this effect.
The project will involve using large population datasets and consortia (e.g., Avon Longitudinal Study of Parents and Children (ALSPAC; http://www.bristol.ac.uk/alspac/researchers/our-data/), UK Biobank) and techniques in genetic (e.g., Mendelian randomization) and observational epidemiology. This is predominantly an epidemiology-based project, although there is an opportunity for in vitro/ex vivo work on tissue and cell lines.
The post-holder will be supported by a supervising team providing training and oversight as required:
* Dr Matthew Butler, MRC Clinician Scientist and Clinical Senior Lecturer
* Prof Gavin Welsh, Professor of Cell Biology
* Prof Simon Satchell, Professor of Renal & Vascular Medicine
What will you be doing?
* Run this research project including designing and conducting experiments, analysing data and presenting research findings in various settings, under the support and direction of the supervisory team.
* Work with big data including bioinformatic data and epidemiological data from ALSPAC, UK Biobank and other publicly available datasets
* Be part of the Bristol Renal and wider Bristol cardiovascular research community under the Bristol Heart Institute.
* Prepare manuscripts for publication in high-impact journals.
You should apply if:
* You want to join a large, friendly research group and take advantage of career development opportunities in renal research and related academic skills.
* A PhD or equivalent qualification in a relevant field is essential, with a strong track record in laboratory-based discovery research.
* Experience with big data and statistical analysis is required; experience in renal/diabetes and/or glycobiology research is highly desirable, as is expertise in techniques relevant to this project.
* Ability to work independently and as part of a team, with strong critical thinking and excellent organisational skills.
Additional information
For informal queries about the role please contact:
Professor Simon Satchell, Professor of Renal & Vascular Medicine, s.c.satchell@bristol.ac.uk
Advert closing: This advert will close at 23:59 UK time on Wednesday 22 October 2025.
#J-18808-Ljbffr