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PhD Studentship: Chemical Biology of the Genome and the Epigenome, Cambridge
Client:
University of Cambridge
Location:
Cambridge, United Kingdom
Job Category:
Education
EU work permit required:
Yes
Job Reference:
0c4894dfeb48
Job Views:
7
Posted:
26.04.2025
Expiry Date:
10.06.2025
Job Description:
We invite applications from creative and enthusiastic individuals interested in joining Professor Sir Shankar Balasubramanian's group for a 4-year PhD studentship, working on a multidisciplinary project exploiting both chemistry and biology to explore fundamental mechanisms of genome function.
The project focuses on three main areas:
1. Investigation of the structure and function of DNA and RNA G-quadruplexes (G4s), important for control of transcription, translation, and other key processes, with implications for cancer research.
2. Development of techniques to map small molecule binding sites on DNA and RNA, and identify associated proteins.
3. Study of base modifications in nucleic acids, elucidating their effects on DNA structure, recognition, and cellular function.
All projects involve cutting-edge technologies in chemical biology, molecular biophysics, structural biology, and genomics.
The studentship is based in the Balasubramanian lab at the Yusuf Hamied Department of Chemistry, with collaborative work at the CRUK Cambridge Institute.
Applicants should have (or expect to obtain) at least a UK upper second-class Master's degree in a relevant chemical or biological discipline, with a strong background in organic chemistry and/or chemical biology. Knowledge of nucleic acid chemistry and molecular biology methods is desirable. Candidates should demonstrate motivation, creativity, independence, and strong communication skills.
The studentship begins in October 2025, covering tuition fees and providing a maintenance grant. Outstanding overseas applicants may be supported in their scholarship applications.
The University promotes equality, diversity, and inclusion and welcomes applications from all sectors of society.
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