Overall purpose:
To advance our understanding of genome architecture and epigenetic regulation using cutting-edge single-cell and multi-omics technologies.
About the Laboratory:
The Vaquerizas Laboratory at the MRC Laboratory of Medical Sciences is internationally recognised for pioneering research in 3D genome organisation, epigenomics and single-cell multiomics (, Hug et al., Cell 2017; Galan et al., Nature Genetics 2020; Ing-Simmons et al., Nature Genetics 2021). Our most recent work focuses on understanding key processes in human and mouse development, male infertility, and epitranscriptomics, using cutting-edge genomic and transcriptomic technologies.
We take a multidisciplinary approach, integrating molecular biology, genomics, computational biology, and systems-level analyses to address fundamental biological questions. The lab fosters a collaborative and supportive research environment, encouraging independent scientific growth and offering access to state-of-the-art core facilities and comprehensive training opportunities.
Thematic Research Interests:
1. Single-cell multiomics and spatial transcriptomics
2. 3D genome architecture and nuclear organisation
3. Epigenomics and epitranscriptomics in development and disease
4. Model systems including human, mouse, flies, worm and beyond
5. Personal research interests and innovative ideas within these themes are strongly encouraged
About the Role:
This hybrid role combines active research with responsibilities that support laboratory operations, such as overseeing organisation, procurement, equipment maintenance, and safety compliance. The candidate will have the opportunity to pursue their own research within the lab’s focus areas while helping maintain a productive and well-functioning lab environment. The role may also involve mentoring junior lab members and contributing to grant writing and protocol development.
Main duties / key responsibilities:
6. Design, plan, and conduct high-quality, independent research aligned with the project aims
7. Critically analyse, interpret, and present experimental data with scientific rigor and reproducibility
8. Develop, refine, and implement experimental methods, protocols, and analytical techniques
9. Stay current with relevant scientific literature and integrate new findings and methodologies into ongoing research
10. Collaborate effectively with internal lab members and external partners, including participation in interdisciplinary projects
11. Provide mentorship, training, and guidance to junior researchers and PhD students
12. Contribute to the academic life of the institute by attending and participating in lab meetings, journal clubs, and seminar programmes
13. Present research findings at national and international conferences and meetings
14. Publish results in high-quality, peer-reviewed scientific journals
15. Support the smooth running of the laboratory by contributing to shared responsibilities and day-to-day operations
16. Support the preparation of research grant applications, including contributing to the development of proposals and gathering preliminary data
Additional information:
These are MRC Postdoctoral Research Scientist positions designed to support postdoctoral training and help establish successful research careers. During the fellowship, we are committed to providing mentorship for career development, including support for communication skills, grant writing, and scientific leadership.
We offer a highly attractive benefits package, including a competitive salary and pension scheme, as well as access to world-class research facilities and training programmes.
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Education / Qualifications / Training required (will be assessed from application form):
Essential:
17. PhD (or equivalent) in a relevant field (, bioinformatics, computational biology, molecular biology, cell biology, biochemistry, developmental biology, genetics), or in the final stages of completing a PhD
Previous work experience required (will be assessed from application form and at interview):
Essential:
18. Strong research background in relevant techniques
Desirable:
19. Previous postdoctoral experience
20. Experience or willingness to undertake lab managerial tasks
21. Experience with single-cell multiomics, spatial transcriptomics, or 3D genome technologies
Knowledge and experience (will be assessed from application form and at interview):
Essential:
22. Strong conceptual understanding of genomics, gene regulation, developmental biology, computational biology approaches
23. Experience in generating high-quality figures for publication
24. Excellent written communication skills in English
Desirable:
25. First-author publication or pre-print
26. Experience in assembling manuscripts for publication
27. Experience presenting scientific data at national or international conferences
Personal skills / Behaviours / Qualities (will be assessed at the interview):
Essential:
28. Enthusiastic and motivated, with a genuine interest in scientific discovery and learning
29. Independent research capability, including the ability to manage and drive projects autonomously
30. Collaborative mindset, with the ability to work effectively in a team-oriented research environment
31. Eagerness to learn, particularly in computational and analytical approaches
32. Creativity and problem-solving skills, especially when troubleshooting complex challenges
33. Excellent verbal communication skills in English, with the ability to present ideas clearly and confidently
34. Good interpersonal skills, including the willingness to give and receive help and feedback
35. Commitment to knowledge sharing and mentoring within the group
36. Highly organised and diligent, with strong attention to detail
37. Adaptability and openness to integrating new techniques and collaborating across disciplines
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