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Postdoctoral Research Assistant in single-molecule biophysics of DNA damage-induced transcription stress, Oxford
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Client:
University of Oxford
Location:
Oxford, United Kingdom
Job Category:
Other
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EU work permit required:
Yes
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Job Reference:
383de6f97493
Job Views:
4
Posted:
05.05.2025
Expiry Date:
19.06.2025
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Job Description:
Condensed Matter Physics, Department of Physics, Clarendon Laboratory Building and Kavli Institute, Oxford, OX1. We are looking to hire an outstanding experimentalist for an exciting project at the interface of biophysics and biochemistry that aims to understand the response of RNA polymerase to DNA damage-induced transcription stress. This is a fixed-term position for 3 years.
What are you going to do?
* Employ advanced biophysical instrumentation based on optical trapping or fluorescence microscopy to study RNA polymerase and its response to DNA damage-induced transcription stress;
* Develop an interdisciplinary skillset by acquiring practical knowledge of protein purification, ensemble biochemistry, and sample preparation to support your biophysical studies;
* Interact with biochemist and structural biology collaborators at Oxford and in the Netherlands (Erasmus MC and Netherlands Cancer Institute) in collaborative projects;
* Suggest ways to expand the interdisciplinary skillset as needed for the project's benefit;
* Employ simulations and data analysis routines to analyze your data;
* Publish your results with collaborators;
* Have the opportunity to gain teaching experience and improve leadership skills while guiding undergraduate and graduate students.
About the project
Requirements
For this innovative, interdisciplinary project, we seek an excellent scientist with:
* A successfully completed Ph.D. degree (or close to completion) in quantitative biochemistry or biophysics;
* Practical experience and scientific maturity in these areas;
* Strong experimental and quantitative skills;
* An interest in working at the interface of biophysics, biochemistry, and structural biology (and developing relevant skills if not already present);
* An independent, well-organized, and reliable work style, with the ability and interest to work in a small team;
* Good interpersonal communication skills and a strong interest in the broader fields of replication and transcription, contributing to collaborative work and our interactive lab culture.
We welcome friendly and driven colleagues to enrich our team. We aim to onboard our new colleague in fall 2025.
Who are we?
Information and application
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