LC-MS Scientist
CK Group are recruiting for a lab-based LC-MS Scientist to join a precision medicine company based near Manchester.
Company:
Our client is developing next-generation diagnostic tests to help clinicians prescribe the right drug, for the right patient, at the right time. They are developing LC-MS proteomic biomarker discovery platforms and clinical assays to predict drug response in a clinical setting.
The Role:
1. Support the development of biomarker discovery platforms and resulting clinical assays.
2. Be involved in a variety of projects that aim to expand the portfolio of proteomic assays
3. Sits within the LC-MS/MS technical operations team and involves operation of LC-MS/MS systems and method development
Your Background:
4. Ph.D. in proteomics or protein biochemistry applied to the investigation of mammalian cell biology
5. Expertise in LC-MS/MS proteomics - hands-on experience running/operating high-end LC-MS/MS systems (including hands-on experience calibrating the MS systems, basic maintenance of LC-MS/MS, renewing buffers, running QCs, interpreting data, and reporting QC outputs).
6. Experienced in preparing samples using proteomic workflows for LC-MS/MS analysis.
7. Experience working with multiple sample types (e.g. cell lines, blood, solid tissue).
8. Knowledge and understanding of fundamental principles of biochemical and molecular biological systems.
Desirable:
9. Experience analysing large sample sets, across multiple batches.
10. Experience using software for the identification, characterisation and quantification of peptides and proteins from LC-MS/MS raw data.
11. Expertise in the utilisation of LC-MS/MS proteomic technologies for the identification and validation of clinical biomarkers.
12. Experience in automation of sample preparation workflows using liquid handlers.
13. Experience building targeted (e.g., PRM/SRM) or untargeted (e.g., DDA/DIA) methods for proteomics.