Role
In this postdoctoral role you will use and further develop home-built millisecond timescale single-molecule optical microscopy and biophysical analysis to enable development and application of new biophysics instrumentation for super-resolution fluorescence microscopy optical microscopy and microfluidics modules. You will also develop, integrate and apply control software and new image analysis code. You will help to further develop and apply home-written single-molecule tracking and quantification software. Your innovative research will enable imaging and tracking of a range of fluorescently-labelled protein and RNA aggresome components in addition to components of other cellular processes associated with aggresomes. Your experiments will involve imaging of live bacterial cells, “semi vivo” extracted aggresomes and reconstituted aggresomes in vitro. You will also help to establish new condensate modelling strategies including aspects of molecular dynamics and coarse-grained simulations. You will combine experimental and computational approaches to quantify aggresome dynamics and microrheology.
Skills, Experience & Qualification needed
You will have:
1. A relevant PhD in the field of Single-Molecule Biological Physics, or a related subject
2. An interest in the subject matter of the project
3. Practical experience in design and development of optical microscopy
4. Practical experience in millisecond single-molecule fluorescence microscopy
5. Experience of developing single-particle tracking software
6. Practical experience in molecular dynamics simulations
7. Attention to detail, a commitment to performing high quality research and a collaborative ethos with a willingness to work positively and proactively with colleagues in other departments and institutions.
8. The ability to efficiently meet deadlines, to disseminate research results professionally in written and oral form and have the initiative to plan research programmes.
9. Excellent communication skills are essential, and you should be keen to develop project/team leadership skills
Interview date: To be confirmed