Metagenomics Research Scientist
Applications Close: 30 September 2025
Salary: £37,500 - £42,000 per annum
Contract Length: full time until funding end date of 31 March 2028
We are looking for a Research Scientist to join the Laboratory of Dr Hildebrand at the Quadram Institute.
In this BBSRC-funded position, the impact of plant-based diets on the gut microbiome will be explored in metagenomes, including tracing bacterial strains, reconstructing their genomes and metabolic food-webs in the gastrointestinal ecosystem. This will be used to understand the impact a changing environment (food sources, immune system, invading pathogens) have on ecosystem stability. Questions we will be asking are, for example:
1. How can food-derived pathogens be effectively prevented from colonising the gastrointestinal tract?
2. Does switching to a plant-based diet lead to a destabilised gut ecosystem (or reverse)?
3. How can the gut microbiome supplement essential micronutrients to the human body?
To answer these questions, the postholder will be primarily working with metagenomic data from diet interventions, using machine learning to predict genomes, functions and ecosystem states (similar to previous work, see doi: 10.1038/s41531-025-00885-5, 10.1016/j.chom.2023.05.024, 10.1016/j.cgh.2024.11.006, 10.1111/1751-7915.14396).
The work will build on bioinformatic tools available in the group (www.falk.science/software, www.github.com/falklab), that will be further refined/ newly developed to enable cutting-edge bioinformatic approaches in the project.
Long-term, this research will contribute to developing pre-/pro-biotic strategies to reduce autoinflammatory disease and enable healthy aging in a wide population. In addition, the postholder will be involved in organizing group tasks, such as helping in supervising junior researchers, submitting grants, developing new research programmes and organising outreach events.
The environment
The Hildebrand group uses metagenomics to research the diversity, community interactions, and evolution of microbes in communities using custom software solutions.
The Quadram Institute is based on the Norwich Research Park, which is one of the largest single-site concentrations of research in food, genomics, and health in Europe. The Park hosts four BBSRC Institutes (including Earlham), 17,000 students, 3,000 full-time researchers and clinicians, and over 115 companies. The outstanding reputation of our researchers is internationally recognised, with 10 of the Park’s scientists in the top 1% of the “most highly cited” in the world, including Dr Falk Hildebrand.
The applicant will have direct access to established PacBio/ONT, Hi-C and single cell sequencing facilities, as well as one of UK’s largest HPC cluster at the NRP.
The ideal candidate
The applicant needs to hold a PhD (or equivalent) in biology, bioinformatics, computer science or a related discipline with a background and/or interest in at least one of the following subjects:
– Microbiomes, metagenomics, evolution & biodiversity
– Public health, nutrition & metabolic modelling
Basic statistics and programming skills (either R, python, Perl, C++, or equivalent) is expected. Specialised skills will be taught and developed through mentorship and collaborations.
Additional information
Salary on appointment will be within the range £36,720 to £42,000 per annum depending on qualifications and experience. This is a full-time post contracted until the funding end date of 31 March 2028.
For further information and details of how to apply, please visit our HR website or contact the Human Resources team on 01603 450814 or nbi.recruitment@nbi.ac.uk quoting reference 1004953. This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. Please contact the Human Resources Team if you have any questions regarding your application or visa options.
We are committed to equity, diversity and inclusion, and welcome applications from all sectors of society. The Institute values of Respect, Innovation, Collaboration and Excellence are at the heart of all we do, and we expect all employees to share and display these values. To support our commitment, we have a range of family, faith and diversity friendly working arrangements to help all staff achieve excellence in their area of work.
As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.
The closing date for applications will be 30 Sept 2025
The Quadram Institute Bioscience is a registered charity (No. 1058499) and is an Equal Opportunities Employer.
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