Applications are invited for a Research Associate in Oligonucleotide Disposition at the Centre for Applied Pharmacokinetic Research (CAPKR) within the Division of Pharmacy and Optometry. The post is fixed-term for 24 months.
Responsibilities
1. Establish novel in vitro assays to quantify siRNA uptake, intracellular distribution, and effect in primary cultured hepatocytes.
2. Use in vitro data to inform mechanistic PBPK-PD models for in vivo oligonucleotide disposition and effect.
3. Develop and explore in vitro methods to assess siRNA cellular kinetics using techniques such as subcellular fractionation, live-cell imaging, RT-PCR, and ELISA.
Candidate Requirements
* Hold a PhD in biomedical or pharmaceutical research.
* Experience with cell-based assays measuring biological or pharmacological processes.
* Experience with molecular techniques (RT-PCR, ELISA), proteomic analyses, or mathematical modeling.
* Ability to work in multi-disciplinary teams.
Note: Applicants requiring UK visa sponsorship must obtain an ATAS certificate prior to visa application.
Benefits
* Market-leading pension scheme.
* Employee health and wellbeing services, including Employee Assistance Programme.
* Generous annual leave entitlement plus bank holidays.
* Additional paid closure over Christmas.
* Discounts at major retailers.
We are an equal opportunities employer welcoming applicants regardless of age, sex, gender, ethnicity, disability, sexual orientation, or transgender status. We support flexible and hybrid working arrangements.
Enquiries should be directed to Dr. Daniel Scotcher at daniel.scotcher@manchester.ac.uk. General enquiries: People.recruitment@manchester.ac.uk. Technical support: https://jobseekersupport.jobtrain.co.uk/support/home.
The vacancy closes at midnight on the specified deadline. Refer to the Further Particulars document for person specification criteria.
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