Role: Principal Scientist- Non-Clinical PKPD
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Location: Slough, Hybrid with 2 days in the office
Company: A Global Pharmaceutical Company
Job Summary
The Non-Clinical PKPD team is part of the newly established Quantitative Clinical Pharmacology function within the Early Clinical Development and Translational Sciences division.
This group is committed to applying integrated quantitative methodologies as a strategic driver from target identification through to market, aiming to deliver innovative solutions to patients.
We lead the quantitative strategy for pharmacokinetics and pharmacology—including PKPD, systems modelling, and clinical pharmacology/pharmacometrics—alongside DMPK activities throughout the full lifecycle of drug development.
Collaboration is central to our approach, working closely with teams across Early Clinical Development & Translational Sciences, which provides strategic support in bioanalysis, immunogenicity, safety, pathology, and regulatory affairs.
We are currently seeking a motivated and communicative professional for a one-year contract role. The ideal candidate will have hands-on experience in non-clinical PKPD and toxicokinetics analysis and reporting, and thrive in a matrix team environment.
Role and Responsibilities
* Lead and contribute to the design and execution of non-clinical PKPD and GLP toxicokinetics studies
* Provide scientific input into protocol development and regulatory study designs
* Collaborate with project team members (e.g., Non-Clinical Safety, Bioanalysis, Clinical Pharmacology) and CROs to ensure data quality
* Ensure compliance with GLP standards and deliver regulatory-ready data packages
* Maintain clear communication with team members to align on project requirements and timelines
* Analyze and present interim and final PKPD/toxicokinetic data to stakeholders in a timely manner
* Prepare comprehensive study reports and contribute to regulatory submission documentation
* Support drug candidate progression by deepening understanding of pharmacology and PKPD
* Represent the team internally and externally, helping to elevate the scientific profile of Non-Clinical PKPD and Translational Science
Skills and Experience
* Advanced degree (PhD, MSc, or BSc) in a relevant field such as quantitative pharmacology, pharmacokinetics/pharmacodynamics, or DMPK
* Minimum of 5 years of practical experience in PKPD data analysis within a pharmaceutical or CRO setting
* Strong grasp of pharmacologic principles related to disease mechanisms and drug action
* Proven track record in designing and executing non-clinical PKPD studies and preparing high-quality data packages for regulatory submissions
* Experience working in cross-functional teams to develop study protocols and analyze/report PKPD and GLP toxicokinetics data
* Proficiency in Phoenix WinNonlin is essential; familiarity with tools like Berkeley Madonna and/or R is a plus
* Ability to manage multiple projects simultaneously and communicate effectively with diverse stakeholders
* Excellent written and verbal communication skills, with a demonstrated ability to produce regulatory-standard reports
* A history of scientific publications or external contributions in PKPD is advantageous