Overview
We are seeking an ambitious and creative chemical biologist with strong synthetic chemistry skills to join the group of Prof Ed Tate at Imperial College, working on design and application of disruptive new technologies for novel antibody-drug conjugate (ADC) discovery. The position is available full time starting by early 2026, with the potential for extension.
What you would be doing
You will be responsible for design, synthesis and application of novel selective linkers for targeted delivery, with a focus on linkers for ADCs, using a currently undisclosed proprietary in-house novel linker discovery platform. This work will involve screening patient tissue samples to generate massive substrate profile datasets in high throughput; application of in-house machine learning algorithms to identify optimal linker activity and selectivity; synthesis and characterisation of linker candidates; and proof of concept studies to demonstrate their utility in ADC designs.
What we are looking for
Essential criteria for the role include:
* Hold, or near completion of, a PhD qualification in an area closely related to the project field, or an equivalent level of professional qualifications and experience
* Strong research track record relative to experience, in academia and/or industry
* Knowledge of linker-relevant synthetic methods.
Desirable experience for this role includes one or more of the following: Design and synthesis of ADC linkers, or related conjugates, experience in solution and/or solid phase peptide synthesis, experience in characterisation of antibody conjugates, experience with machine learning analysis of large datasets, experience working in a team setting and/or with external collaborators, experience in handling biological samples (e.g. tissues, cell lines).
What we can offer you
Working within the Tate group would give you the opportunity to work with >60 scientists at all levels from undergraduates to postdoctoral researchers with our state-of-the-art labs in West London. You will be joining a team with an excellent track record in the areas of antimicrobial resistance and drug discovery.
* The opportunity to continue your career at a world-leading institution and be part of our mission to continue science for humanity.
* Grow your career: Gain access to Imperial’s dedicated career support for researchers as well as opportunities for promotion and progression
* Sector-leading salary and remuneration package (including 41 days off a year and generous pension schemes).
Further information
Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant.
If you require any further details on the role please contact: Professor Ed Tate: e.tate@imperial.ac.uk
You will be based at White City Campus, with travel to the Francis Crick Institute required.
Seniority level
* Associate
Employment type
* Full-time
Job function
* Research
* Higher Education
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