Research Associate in Therapeutic Discovery - INTERNAL ONLY - Strand, London, WC2R 2LSTHIS VACANCY IS OPEN TO INTERNAL APPLICANTS ONLYAbout usThe primary research interest of the group involves understanding the pathophysiology of Alzheimer’s disease (AD), to identify potential therapeutic target(s) to combat cognitive decline. It is widely believed that changes in the number of synapses are associated with numerous brain disorders, including neurodegenerative disease and mental health. The proposed research will involve performing comprehensive analysis of various disease models and therapeutic interventions, with a specific emphasis on quantifying changes in neurophysiological function, synapse structure, and, altered protein interactomes. Ultimately, the research aims to shed light on the impairment of key processes in different pathological contexts. About the roleWe are seeking to appoint a research associate to Professor Cho’s Synapse and Therapeutic Discovery Laboratory, to undertake the research project “The role of SHIA6 in synapse protection in humanised models”. You will be responsible conducting whole-cell patch clamp electrophysiology and multiphoton assays for organotypic slice cultures and iNeurons. Additionally, you will be expected to prepare the slice cultures and iNeurons. We are looking for an individual who is not only proficient in neurophysiology and multiphoton imaging but also possesses a passion for contributing to cutting-edge research. This is a full-time post, and you will be offered a fixed term contract for 18 months in the first instance. Research staff at King’s are entitled to at least 10 days per year (pro-rata) for professional development. This entitlement, from the Concordat to Support the Career Development of Researchers, applies to Postdocs, Research Assistants, Research and Teaching Technicians, Teaching Fellows and AEP equivalent up to and including grade 7. Visit the Centre for Research Staff Development for more information. About youTo be successful in this role, we are looking for candidates to have the following skills and experience: Essential criteriaPhD awarded in relevant subject area*Experience in whole-cell patch clamp electrophysiology Experience in confocal/multiphoton imaging from live tissue samples (e.g. glutamate uncaging, FRAP, calcium imaging) Experience in tissue culture including, organotypic brain slice, dissociated neurons, and iNeuron Knowledge of molecular mechanisms of neurodegenerative disease or synapse biology Attention to detail and high standards of accuracy in all work An ability to work independently and within a team Willing to work occasionally during weekends and bank holidays Desirable criteriaExperience of plasmid cloningProtein-protein interaction assay by co-IPDownloading a copy of our Job DescriptionFull details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the page. This document will provide information of what criteria will be assessed at each stage of the recruitment process. * Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.