Principal Scientist Cell-based Assays
Medicines and Healthcare Products Regulatory Agency (MHRA) is seeking a Principal Scientist to lead a team of analytical scientists focused on cell‑based assays for the characterisation of biological medicines.
Key responsibilities
* Ensure analytical assays are performed in compliance with ISO17025, including assay development, validation and troubleshooting.
* Manage day‑to‑day implementation and delivery of improvements in patient outcomes through resource organisation, process improvement and changes in working practice, including training and innovative assay development.
* Advise, supervise and train staff in specific assays and the administration of control testing.
* Engage with stakeholders across the agency, national control laboratories and manufacturers to ensure quality of service and patient access to medicines.
Qualifications and skills
* Extensive experience working within a ISO17025 quality management system.
* Extensive experience with fluorometric, microscopy, foci‑forming assays, fluorescence‑activated cell sorting (FACS), plaque‑forming and plaque‑reduction neutralisation assays.
* Experience using a Laboratory Information Management System (LIMS) and analysing large complex data sets.
* Strong leadership skills, ability to create a collaborative environment and respond effectively to change.
* Excellent communication skills and ability to engage a wide variety of stakeholders.
* PhD in a relevant field or equivalent extensive experience with analysis of biological medicines, including vaccines.
Employment details
Location: South Mimms, Hertfordshire, UK
Type: Full‑time permanent
Closing date: 14 December 2025
How to apply
Please apply through the MHRA website – NHS Jobs applications will not be accepted.
Contact
For assistance applying, contact careers@mhra.gov.uk
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