Transition Bio is an innovative, early-stage biotechnology company with the vision of being the world leader in drug discovery targeting biological condensates. At Transition Bio, multidisciplinary teams with diverse skillsets in biology, biophysics, chemistry, engineering, and machine learning work closely together, building first-in-class technology for high-throughput screening to aid hit identification and driving drug discovery. With close affiliation to Cambridge and Harvard universities, our approach is truly original and encompasses a growing collection of novel technologies and methodologies.
The Opportunity
We are seeking an outstanding and highly motivated medicinal chemist to join our research group at Transition Bio, where we are discovering & developing drugs that modulate biomolecular condensates. Our drug discovery engine (CONDENSOMICS™) is built on droplet microfluidics & machine learning, as we believe having the right tools is key to unlocking an exciting new field. As a critical part of the internal drug discovery team and working closely with external providers of chemistry and ADME services, this individual will contribute to discovery programs across multiple indications, from target discovery & validation through hit-to-lead and lead optimization activities.
The successful candidate will have strong interpersonal skills and leadership qualities, will have demonstrated a successful track-record working with CROs and contributing to delivering projects against challenging targets, and enjoy working in a truly multi-disciplinary environment. This position will report directly to our head of chemistry, and interact closely with Transition Bio colleagues in chemistry, data sciences, biology, and protein sciences, as well as external partners and consultants.
Key Responsibilities
* Lead synthetic chemistry efforts across projects towards milestone achievements through expertise in synthetic chemistry and excellent communication and organisational skills
* Manage outsourced chemistry, establishing and maintaining positive working relationships with internal team and external providers
* Organise information sharing and sample distribution across various sites, continuously improving efficiency of existing workflows
* Work closely and collaboratively with other disciplines and stakeholders (biology, DMPK, toxicology, etc.) in broader drug discovery to help drive programs forward
* Represent Synthetic Chemistry as well as contribute to drug design across all Transition Bio discovery projects
* Support and possibly lead publication efforts to strengthen the company’s external scientific reputation, inc. patent write up and articles
Required Qualifications and Experience
* PhD in Organic Chemistry, or substantial relevant work experience
* Solid industry medicinal chemistry experience with a passion for synthesis
* Recognised expertise in synthetic chemistry and drug discovery process
* Experience working with international CROs, vendors and other external partners through various phases of drug discovery
* Excellent communication and presentation skills, capable of leading complex scientific discussions with partners and reporting back to key stakeholders
* Experience working on diverse range of challenging chemistry, prior exposure to CMC desirable
* Solid understanding of medicinal chemistry principles applied to drug design, including physiochemical and ADME
* Critical but respectful thinking, desire to improve ways of working by bringing and implementing their own ideas
* Evidence of working collaboratively with key related disciplines (Drug Design, DMPK, cell biology, safety, formulation, etc.)
* Familiarity with tools used in drug design
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