Under the guidance of Prof Trevor Graham, we are seeking to recruit a Higher or Senior Scientific Officer to lead molecular genomics and single cell sequencing studies of cancer evolution. The principal duty of the post will be to undertake research into the evolutionary dynamics that underpin colorectal cancer development and response to treatment. The post holder will lead experimental wet-lab work to generate molecular genomics data, particularly single cell data, from patient material, cell lines, organoids and other sample types.
About you
The successful candidate must have:
1. PhD in molecular biology or other relevant area. Undergraduate degree in biological or quantitative subject.
2. Ability to perform advanced NGS experiments for the analysis of cancer genomes
3. Ability to conduct single cell/nuclei dissociation, sorting and NGS analysis in cell lines and/or patient biopsies
4. Proven expertise in advanced NGS technologies, including RNA-seq, DNA-seq, and single-cell sequencing.
5. Hands-on experience with single-cell technologies such as scRNA-seq, scATAC-seq, or spatial transcriptomics.
6. Good communication skills and the ability to interact effectively with other team members.
Department/Directorate Information
The Centre for Evolution and Cancer (CEC), within the Division of Cancer Biology, is a multidisciplinary centre, comprising around 50 staff dedicated to understanding cancer evolution and leveraging this knowledge for translational benefit. Our interests span early detection through to treatment of metastatic disease. The CEC brings together expertise in evolutionary theory, computational biology and bioinformatics together with cutting-edge research ability in cell and molecular biology to provide a stimulating and creative interdisciplinary environment where new approaches to tackling cancer can thrive.
The Genomics and Evolutionary Dynamics team combine molecular and cellular biology together with mathematical and computational modelling to study the evolution of malignancy. We focus on early detection in the gastrointestinal tract, colorectal cancer evolution and treatment response, and pan-cancer genomics. We perform basic research into the biology of the human body in health and disease and translate our findings to improve clinical care of patients affected by cancer.
What we offer
7. A dynamic and supportive research environment
8. Access to state-of-the-art facilities and professional development opportunities
9. Collaboration with leading researchers in the field
10. Competitive salary and pension