Overview
Energy Jobline is the largest and fastest growing global Energy Job Board and Energy Hub. We have an audience reach of over 7 million energy professionals, 400,000+ monthly advertised global energy and engineering jobs, and work with the leading energy companies worldwide.
We focus on the Oil & Gas, Renewables, Engineering, Power, and Nuclear markets as well as emerging technologies in EV, Battery, and Fusion. We are committed to ensuring that we offer the most exciting career opportunities from around the world for our jobseekers.
Research Scientist Oxford At Exogene, we’re reimagining what’s possible in cancer immunotherapy. Our mission is to engineer T-cell receptor therapies that can precisely and powerfully target advanced solid tumours. To do this, we’ve built a proprietary lab-in-the-loop platform that merges generative AI, biophysical modelling, and high-throughput TCR screening to rapidly design, test, and optimise TCRs with exceptional affinity and specificity. This convergence of computation and wet-lab experimentation allows us to go from concept to candidate molecules in record time. We’re developing TCR-based trispecific T cell engagers (TCR-TriTCEs)—a new therapeutic modality designed to overcome the unique challenges of the solid tumour microenvironment. This work spans multiple disciplines, from protein engineering and AI-driven design to in vivo validation and translational development. We are looking for a dynamic research scientist who will help drive the TCR engineering processes and development. The successful candidate will contribute to in vivo and in vitro validation of TCEs. You’ll get involved in purifying recombinant TCRs to perform high-throughput TCR display methods and deep sequencing.
Responsibilities
* Contribute to in vivo and in vitro validation of TCEs.
* Collaboratively design and characterise TCRs for proprietary and partnered disease targets.
* Conduct a suite of protein science operations, including expression, purification, and biophysical analysis.
* Tackle molecular biology duties: cloning, mutagenesis, DNA isolation, and preparing libraries for deep sequencing.
* Manage tissue culture assignments, spanning from media prep and cell line care to cryopreservation.
* Join forces with founders, R&D, academia, and industrial stakeholders to fulfil ambitious R&D objectives.
* Draft, revise, and oversee repertoire of lab protocols.
* Offer essential lab support and uphold facility upkeep.
Skills and Qualifications
* PhD in Immunology, Cell Biology, Biochemistry, or an alike field, paired with at least 1-2 years of relevant lab experience is required.
* Knowledge of molecular biology protocols, with an emphasis on cloning and PCR is required.
* A background in molecular biology, protein expression, purification and biophysical characterisation is preferred.
* Experience in cell and immunological assays (flow cytometry, ELISA etc.) is desired.
* Experience with in vivo and in vitro validation of TCEs (T-cell engagers) in some or all aspects of investigational new drug (IND) approval is desired.
* Experience TCR engineering is desired.
* SOP documentation experience is desired.
* The highest standards in lab precision, record maintenance, and documentation.
* Excellent written and oral communication skills.
* Attributes: Self-starter with sound analytical skills, collaborative, capable of handling multiple projects and deadlines, and able to work in a fast-paced interdisciplinary team.
What We Offer
* Market-competitive salary and stock option package.
* A generous leave policy: 25 days holiday, public holidays, plus a day off for your birthday.
* Access to fully equipped private lab.
* Flexibility to work from home as project demands allow.
* A supportive, cross-disciplinary team fostering a highly collaborative work environment.
How to apply
Launch your journey with Exogene by submitting your CV and a brief cover letter (maximum 400 words) to m.hasan at exogene.co.uk
If you are interested in applying for this job please press the Apply Button and follow the application process. Energy Jobline wishes you the very best of luck in your next career move.
#J-18808-Ljbffr