At Cancer Research UK, we exist to beat cancer
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Cancer Research Horizons are looking to recruit apassionate scientificprofessional toset and drive our computational strategy forthe discovery and validation of novel oncology targets, including through the analysis of patient data.
About Cancer Research Horizons
As the world’s biggest medical research charity,we’vehelped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster.
We have recently developeda new approachto driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK’s established drug discovery teams under one organisation and leadership team, combining our unique pipeline of cancer biology expertise and access to CRUK’s world-class academic network, cutting edge technology platforms and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success.
Based at sites in Cambridge, the CRUK Scotland Institute inGlasgow,andNewcastle University, Cancer Research Horizons employs ~200 staff from both industrial and academic backgrounds
This is a new role for the team and realchance to make a tangible impact from day one.We are looking for candidates who can bring strong experience of AI and machine learning tounlock the power of real patient data.We’rejust scratching the surface, andnow’syour chance to lead the way.InIn thisrole,you will become an integral part of the Cancer Research Horizon Drug Discovery team helping to progress novel cancer targets towards patient benefit.Furthermore,weactively encourage our colleagues to celebrate our science, by attending conferences, presenting posters, giving talks at events and publishing papers.
What will I be doing?
Our new strategy sets out to bring deeper mechanistic understanding at the molecular and cellular level to all stages of projects, from idea to pre-clinical Candidate. Reporting directly to the Leader of our Quantitative Biology team,we are looking for an experienced computational biologist todevelop, evaluate, and apply both existing and novel machine learning and AI approaches to integrate multi-modal oncology datasets to generate novel testable hypotheses.As aPrincipalComputationalBiologist,you will work closely with bench scientists, bioinformaticians, and statisticians to design functional genomics experiments to test computational predictions and support the analysis and interpretation of downstream validation experiment
In this role you will:
1. Set and drive our computational strategy for the analysis of patient multi-omics datasets to discover novel oncology targets.
2. Evaluate, develop, and implement new and existing machine learning and AI approaches to uncover actionable biological insights from large multi-modal oncology datasets.
3. Provide deep expertise in computational biology and its role in oncology drug discovery.
4. Foster a culture of continuous improvement for our computational and analytical approaches.
5. Provide scientific and strategic leadership in computational biology across CRH.
6. Communicate effectively to influence multiple stakeholders and collaborate across projects and sites, including externally.
7. Promote scientific excellence, through external publication and presentations.
8. Play a pivotal role in training and developing colleagues.
Whatarewelooking for?
9. PhD in bioinformatics, data science, or equivalent
10. Experience within a drug discovery environmentspecifically a pharma or biotech company
11. Experienced in the use and development of machine learning and AI approaches for the integration and analysis of large multi-omics datasets
12. A strategic thinker with proven scientific leadership, including through matrix management
13. Programming experience with tools such as Python
14. Experience adhering to good coding hygiene practices such as documentation, testing, and code review
15. Excellent communication skills, ability to describe complex science in an engaging and inclusive manner.
16. Ability tobuild open and honest relationships andinfluence multiplestakeholders.
17. Ability to workcollaborativelyacrossprojects and sites, also externally
Our organisation values are designed to guide all that we do.
Bold: Act with ambition, courage and determination
Credible: Act with rigour and professionalism
Human: Act to have a positive impact on people
Together: Act inclusively and collaboratively
We’re looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer.
If you’re interested in applying and excited about working with us but are unsure if you have the right skills and experience we’d still love to hear from you.
What will I gain?
Wecreate a working environment that supports your wellbeing andprovide agenerous benefits package, a wide range of career and personal development opportunities and high-quality tools. Ourpolicies and processes enable you toimprove your work-life balance, take positive steps in your career and achieve your personal wellbeing goals.
You can explore our benefitsby visiting ourcareers web page.
How do I apply?
We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we won’t be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively.