Company Description
AMPLY Discovery is an AI-enabled drug discovery company developing novel therapeutic programmes from underexplored areas of biology, including the non-coding genome. Our platform integrates computational target discovery, multiomic data analysis, cell biology, target validation and experimental therapeutics to identify and prosecute new drug targets in areas of high unmet medical need. AMPLY’s oncology programmes are focused on identifying and validating novel cancer vulnerabilities, including lncRNA-associated targets and pathways, with an initial emphasis on hard-to-treat cancers such as triple-negative breast cancer and haematological malignancies. The company is now seeking a cell biology-focused Research Scientist to support the experimental validation and progression of oncology discovery programmes.
Role Description
The Research Scientist will work as an active member of AMPLY’s drug discovery team, supporting cell biology experiments across AMPLY’s oncology programmes. The position will be based at the Future Medicines Institute (FMI) Industry research hub at Queen’s University Belfast and work as part of an existing Amply-FMI R&D programme. The new role will focus on supporting this existing Amply R&D programme at FMI conducting cell-based assays including siRNA/ASO-mediated target knockdown, mechanism-of-action studies and phenotypic screening. The successful candidate will generate high-quality experimental data to support target prioritisation, therapeutic hypothesis testing and progression of AMPLY’s internal and partnered oncology programmes.
Role Type
Fixed Term (1 year)
Qualifications
The successful candidate should have:
* BSc or MSc in biology, pharmacology, biomedical sciences or a related life sciences discipline.
* Strong practical experience in molecular biology and mammalian cell culture techniques.
* Experience in executing cell-based assays such as viability, proliferation, apoptosis, cell cycle, migration/invasion or pathway response assays.
* Experience with gene knockdown or target perturbation methods, such as siRNA, ASO, shRNA and CRISPR-related approaches.
* Strong laboratory documentation and data-management discipline.
* Ability to work independently while contributing effectively to a multidisciplinary team.
* Clear written and verbal communication skills.
Experience in one or more of the following would be advantageous:
* 2 yrs + relevant laboratory-based research experience.
* RNA biology and RNA-targeted therapeutics discovery.
* High-content imaging, flow cytometry or automated cell-based screening.
* Experience with transcriptional analytical methodologies such as qPCR and/or RNA-Seq analysis
* 3D tumour models, spheroids, co-culture systems or patient-derived models.
* Drug discovery screening workflows including high throughput technologies
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