Role Summary
We are seeking a Principal Scientist to drive siRNA lead development across multiple therapeutic programs. This role will guide the progression of siRNA candidates from sequence prioritisation through in vivo validation and candidate nomination. The successful candidate will work cross‑functionally with bioinformatics, chemistry, translational biology, and external CRO partners to design screening strategies, interpret complex datasets, and advance siRNA therapeutics toward development candidates. This is a scientific leadership role focused on experimental strategy, program advancement, and data‑driven decision making, rather than hands‑on laboratory work.
Key Responsibilities
* siRNA Lead Development & Optimisation
o Collaborate with bioinformatics teams to evaluate and prioritise siRNA sequences targeting disease‑relevant genes.
o Design screening strategies and experimental workflows to evaluate siRNA candidates in in vitro systems.
o Interpret screening results to identify potent and specific siRNA leads and guide progression of candidates.
o Oversee progression of prioritised siRNA candidates through in vivo validation in relevant disease models.
* Lead Optimisation & Candidate Advancement
o Work closely with chemistry teams to guide structure–activity relationship (SAR) optimisation to improve potency, stability, and delivery characteristics.
o Collaborate with bioinformatics scientists to assess and mitigate potential off‑target effects through computational and experimental approaches.
o Integrate data across in vitro and in vivo studies to prioritise candidates and support progression toward candidate nomination.
* Cross‑Functional Collaboration
o Coordinate siRNA activities across internal teams and external CRO partners.
o Manage and guide external CROs conducting screening and in vivo studies.
o Work closely with teams in bioinformatics, chemistry, pharmacology, translational biology, and disease biology to advance programs efficiently.
* Scientific Leadership
o Provide strategic input into siRNA screening strategies and therapeutic development approaches.
o Communicate program progress and scientific insights to internal stakeholders and leadership.
o Contribute to platform development and best practices for siRNA lead optimisation and development.
Person Specification
* PhD in Molecular Biology, Genetics, Biochemistry, Pharmacology, Neuroscience, or related field.
* Extensive experience in siRNA therapeutics in an industry setting.
* Demonstrated experience advancing siRNA programs through lead optimisation and ideally toward candidate nomination.
* Deep understanding of RNA interference biology and siRNA therapeutic development.
* Experience with siRNA sequence prioritisation and screening strategies.
* Experience interpreting in vitro and in vivo data supporting RNA therapeutics programs.
* Familiarity with siRNA chemistry and SAR optimisation strategies.
* Experience collaborating with bioinformatics teams to evaluate off‑target risks and sequence specificity.
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