Overview
Senior Principal Scientist, Biologics AI Innovation role at AstraZeneca. Based at the Cambridge, UK R&D center, the position leads AI strategies transforming Biologics drug discovery and design. The ideal candidate will spearhead computational approaches, drive design and optimization of Biologics-based therapeutics, and collaborate across functions at the interface of AI, structural biology, and drug discovery.
Location
Cambridge, United Kingdom
Responsibilities
* Lead the development and application of advanced AI/ML models for the design, engineering, and optimization of biologics (e.g., monoclonal antibodies, proteins, nanobodies, multispecifics).
* Collaborate with multidisciplinary teams to innovate and automate workflows, integrating experimental and computational platforms.
* Mentor and guide junior data scientists, bioinformaticians, and molecular engineers in the application of data-driven approaches.
* Evaluate emerging technologies and external partnerships relevant to AI-enabled Biologics Engineering.
* Lead or contribute to the publication of high-impact scientific articles and present at internal and external conferences.
* Establish best practices for integrating large, complex biological datasets (protein sequences, structures, biophysical data) into model development pipelines.
* Translate scientific advances into actionable strategies for Biologics program teams, driving impact from hit discovery through candidate optimization.
* Champion innovation in AI, data privacy, and ethical use of machine learning in biologics research.
Essential Requirements
* Ph.D. or equivalent in Computational Biology, Structural Biology, Bioinformatics, Computer Science, Engineering, or a related field.
* Strong experience in biopharmaceutical R&D or academia, with a track record of AI/machine learning innovations for biologics.
* Deep expertise in protein modeling, biologics design, or related fields, with hands-on experience deploying deep learning or advanced statistical models.
* Proficiency with modern AI/ML tools and frameworks (e.g., PyTorch, TensorFlow, scikit-learn).
* Experience working with large, complex biological and biophysical datasets.
* Excellent communication, prioritisation, leadership, and cross-functional collaboration skills.
* Strong publication record in peer-reviewed journals with demonstrated impact on biologics drug discovery programs.
Preferred Requirements
* Experience leading teams or complex scientific projects in an industrial research setting.
* Knowledge of structure-based drug design, antibody engineering, or protein-protein interaction modeling.
* Familiarity with laboratory automation, high-throughput screening, and experimental design for biologics discovery.
* Awareness of regulatory, ethical, and privacy considerations for data-driven drug discovery.
Why AstraZeneca?
Join a vibrant scientific community in Cambridge within AstraZeneca’s R&D network to contribute to an innovative Biologics Engineering group leveraging AI to shape the future of medicine. We offer a collaborative and inclusive culture, world-class facilities, and opportunities to make a global impact.
Application Details
Closing date for applications: COB 26 September 2025
Date posted: 02 September 2025
Location: Cambridge, England, United Kingdom
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