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Job Description
Research Scientist, Protein Engineering
POSITION OVERVIEW:
We are looking for a highly motivated individual to join our team of scientists and contribute towards the development of novel biotherapeutics, focusing on antibody engineering and development. This is a research-based role, working to discover therapeutics for the treatment of autoimmune diseases. Individuals that have protein engineering experience, including next generation cloning techniques, recombinant protein design, production, and characterisation, are desirable. This position also provides an opportunity to work closely with highly diverse and collaborative groups, both internally and externally, to support the delivery of R&D programs at Gilead.
EXAMPLE RESPONSIBILITIES:
* Design and implement protein engineering workflows to support antibody-based therapeutic discovery
* Implement molecular biology cloning strategies, recombinant protein expression (mammalian), purification (AKTA), and characterisation (HPLC, DLS, DSF), including affinity determination (SPR and BLI)
* Generate, analyse, and troubleshoot large-scale data sets, including NGS sequence data, and functional screening data associated with antibody repertoires
* Apply a broad functional knowledge to support team goals and deliver departmental initiatives
* Collaborate with internal teams, as well as external experts, CROs and academic groups, to leverage opportunities, establish best practices, and deliver innovation
* Authors and contributes to presentations, publications, and patents
*
REQUIREMENTS:
We are all different, yet we all use our unique contributions to serve patients. Please see the following for the qualifications and skills we seek for this role.
Minimum Education & Experience
* PhD, or equivalent experience, in Protein Engineering, Biochemistry, or related discipline
* Expertise in protein design, production, and characterisation
* Self-motivated; with strong teamworking skills and experience of collaborating with multi-disciplinary teams
* Good written and oral communication skills
*
Knowledge & Other Requirements:
* Demonstrated ability to be a fast learner
* Ability to be flexible and adaptable to change, to move between projects easily and provide support and expertise where needed
* Practical and analytical abilities with high attention-to-detail as demonstrated through publications, past experiences and/or academic achievements
* Experience in using sequence analysis/molecular biology software, protein expression, purification, and biophysical characterisation
* Desirable experience in molecular modelling, and the use of protein modelling and design software, e.g., Schrodinger, Rosetta, AlphaFold2, MOE, for the design and optimisation of antibody sequences
Equal Employment Opportunity (EEO)
It is the policy of Gilead Sciences, Inc. and its subsidiaries and affiliates (collectively "Gilead" or the "Company") to recruit select and employ the most qualified persons available for positions throughout the Company. Except if otherwise provided by applicable law, all employment actions relating to issues such as compensation, benefits, transfers, layoffs, returns from layoffs, company-sponsored training, education assistance, social and recreational programs are administered on a non-discriminatory basis (i.e. without regard to protected characteristics or prohibited grounds, which may include an individual’s gender, race, color, national origin, ancestry, religion, creed, physical or mental disability, marital status, sexual orientation, medical condition, veteran status, and age, unless such protection is prohibited by federal, state, municipal, provincial, local or other applicable laws). Gilead also prohibits discrimination based on any other characteristics protected by applicable laws.
For Current Gilead Employees and Contractors:
Please log onto your Internal Career Site to apply for this job.