The role
We are looking for an enthusiastic and skilled researcher to work on a genetic epidemiology research project investigating whether adiponectin prevents the development of kidney disease, via the glycocalyx that lines the filtering blood vessels in the kidney. This is a 14 month senior research associate post, joining a 3 yr post after 22 months completion, working in the Bristol Renal group to undertake a Kidney Research UK funded project.
There are three main objectives:
1. The relationship between circulating adiponectin and measures of glycocalyx depth will be examined
2. The causal relationship between circulating adiponectin on diabetic kidney disease (DKD) and chronic kidney disease (CKD), will be explored
3. The causal between circulating levels of adiponectin and albuminuria will be explored, and whether circulating matrix metalloproteinases (glycocalyx sheddases) mediate this effect.
The project will involve using large population datasets and consortia (e.g., Avon Longitudinal Study of Parents and Children (