Job overview
In addition, the postholder will design and develop web portals for data visualisation, support scientists with NGS data analysis and interpretation, and manage data storage, backup and user support. They will also contribute to staff training, documentation and SOPs, ensuring compliance with legal and ethical standards for handling and transmitting genetic and sensitive patient data
Main duties of the job
The main objective of the post holder is to provide expert bioinformatics knowledge and support for the provision and development of next generation sequencing (NGS) data analysis in Clinical Genomics both for diagnostic and R&D applications. They will contribute to the development of analysis pipelines and state of the art web portal necessary to provide an efficient and high quality clinical genomics service for cancer patients. Responsibilities of the post holder will include designing, implementing and maintaining NGS data analysis pipelines for a range of applications including custom enrichment panels, whole exome sequencing, gene expression profiling as well as genome-wide methylation analysis.
In addition, the post holder will also involved in designing web portal for data visulisation and supporting Clinical Scientists and research scientist to analyse and interpret NGS report. Moreover, the post holder will be responsible for storage and backup of NGS data, user support, delivering staff training, writing standard operating procedures and other documents as well as ensuring that the department complies with legal and professional requirements in regards to storage and transmission of patient’s genetic and sensitive data.
Detailed job description and main responsibilities
• To develop and maintain a secure web portal for the NGS data analysis and sharing of clinical data.
• Maintain internal databases, linked to the main public genome databases and North Thames Genomic Laboratory Hub (NT-GLH) central database
• To organise, store and backup data in a timely manner.
Person specification
Skills and Abilities
Essential criteria
1. Educational qualification in mathematics
Personal Qualities
Essential criteria
2. Evidence of personal development
3. Self confident, contributes to laboratory meetings
4. Able to work unsupervised
5. Flexible approach to work, decision maker
Specific Experience
Essential criteria
6. BSc in biological sciences / bioinformatics / computational biology
7. MSc in bioinformatics/computational biology
8. HCPC-Registered Clinical Bioinformatician or working towards registration
9. Good knowledge of open source bioinformatics tools and genomic databases
10. Experience of UNIX/LINUX operating systems to an advanced level
11. Experience of high performance computing systems and parallelising jobs
12. Experience of working in DNA-seq NGS
13. Experience in programming using scripting languages, e.g. Perl, Python, R or Java
14. Experience of working in cancer genetics
15. Experience working in bioinformatics/computational biology
16. Proven ability to organise daily work plans and schedules
17. Ability to automate processes and analysis
Desirable criteria
18. PhD in bioinformatics/computational biology or equivalent experience
19. Experience of working in other NGS applications i.e. RNA-seq
20. Experience with development and maintenance of a web portal
21. Able to perform advanced training and ensuring compliance with professional standards
22. Knowledge of Next Generation Sequencing analysis and data storage in Cloud
Skills and Abilities
Essential criteria
23. Good interpersonal skills
24. Good judgement, analytical, perceptive, eye for detail
25. Able to take specific responsibilities in an area of defined specialist knowledge
26. Able to deal with database/systems trouble shooting
Desirable criteria
27. Awareness of organisational and logistical issues
Personal Qualities
Essential criteria
28. Enthusiasm for job and profession
29. Commitment to team working
Specific Experience
Essential criteria
30. Ability to automate processes and analysis
Desirable criteria
31. Ability to perform complex data audits
32. Knowledge and understanding of ISO15189 standard
33. General understanding of all aspects of quality management
Clinical Responsibility
Essential criteria
34. Understanding of relationship between laboratory investigations, data analysis and clinical practice
35. Awareness of clinical significance of genetic findings and implications for patients
36. Ability to extrapolate from basic information to consider additional investigations to perform
37. Ability to review anomalous / unexpected findings and take further appropriate action
Desirable criteria
38. Ability to manage the bioinformatics workflow on a daily basis
The Royal Marsden values diversity and is committed to the recruitment and retention of underrepresented minority groups. We particularly welcome applications from Black, Asian and minority ethnic candidates, LGBTQ+ candidates and candidates with disabilities.
As a Disability Confident Employer, we are working to create a workplace that enables all staff to reach their full potential. We are committed to this because we know that greater diversity and inclusion will lead to an even greater positive impact for the people we serve.
Due to the high volumes of applications we receive, we reserve the right to close any adverts before the published closing date once we have received a sufficient number of applications. We advise you to submit your application as early as possible to prevent disappointment. Please ensure your information is accurate to avoid errors with processing your application
Flu Vaccination – What We Expect of our Staff
At The Royal Marsden we have an immune compromised patient population who we must protect as much as we can against the flu virus. Each year, seasonal flu affects thousands of people in the UK. Occurring mainly in winter, it is an infectious respiratory disease capable of producing symptoms ranging from those similar to a common cold, through to very severe or even fatal disease.
The wellbeing of our staff and patients is of the upmost importance to us, and it is the expectation of The Royal Marsden that all patient-facing staff have an annual flu vaccination, provided free of charge by the Trust.
Employer certification / accreditation badges
Applicant requirements
You must have appropriate UK professional registration.