Senior Scientist I - Characterisation | CMC - Oxford
To characterise the company's biotherapeutic recombinant T‑cell receptor‑based and related molecules using a wide variety of protein characterisation and mass spectrometry methods. Contribute to the development of characterisation methods for the company's biopharmaceutical products, including peptide mapping (LC‑MS/MS) and intact mass spectrometry analysis.
Immunocore is proud to be an equal‑opportunity employer. We are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.
Key Responsibilities
* Supporting drug substance and drug product impurity characterisation and identification
* Performing protein sequence and post‑translational modification identification, including glycosylation analysis
* Supporting drug substance and drug product process development by performing characterisation of process intermediates
* Contribute to the development of characterisation methods of ImmTAX and other products, including peptide mapping (LC‑MS/MS) and intact mass analysis
* Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products
* Contribute to writing study protocols and reports
* Independently test and, increasingly, lead lines of investigation; propose new experiments based on emerging data and other related information; provide support on technical aspects to others
* Establish and prioritise own work and team‑based projects, making decisions on prioritisation based on overall goals of the team, department and project, using direct evidence and personal experience as guidance
* Share technical knowledge with the wider team and across departments, may also act as a mentor to other colleagues, sharing scientific knowledge; provide analysis of new techniques and theories from outside the company to advance the way the company works; share these with leaders across the department
* Maintain laboratory records: ensure that all records and information are up to date, on time and recorded to the correct standard; support and encourage others to achieve this
* Provide technical guidance on laboratory equipment to others within the team on how to use equipment most effectively
* Report by communicating and presenting research findings at meetings with colleagues, senior management and partners
* Adhere to safe working practices in laboratories according to Immunocore EHS policies
Person Specification
Experience & Knowledge
Essential
* Experience in development of HPLC‑based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies
* Experience of glycosylation analysis of recombinant proteins or antibodies
* Independently coordinated extensive testing of protein biomolecules
* Experience in the characterisation of proteins expressed in both microbial and mammalian systems
* Understanding of expected post‑translational modifications in biological systems
* Worked in a bench‑based biopharmaceutical laboratory environment
* Established as an expert amongst peers in one or more of the following areas:
o electrophoretic
o chromatographic
o mass spectrometry
* Experience in assay development
* Familiar with biopharmaceutical stability study principles and interpretation thereof
* Worked and contributed actively in a diverse team environment
* Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change
* Presented detailed scientific findings and papers to internal and external audiences
Desirable
* Experience of glycosylation analysis of recombinant proteins or antibodies
* Experience with late stage/commercial biopharmaceutical assay development and characterisationFamiliar with the principles of Good Manufacturing Practice (GMP)
* Presented at external conferences
* Led a small project team, formally or informally, through a change in practice including project management
* Understanding of analytical requirements to support materials for use in clinical trials
Education & Qualifications
* Essential: BSc or MSc in biochemistry, biotechnology or related discipline
* Desirable: PhD in related discipline
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