Job Description
Senior Scientist - Mass-spectrometry - Triple Quad
Location: London
Hours: full time permanent - 40 hours per week
Role overview
Lead and deliver client-facing biomarker projects within a Core Labs programme, with a focus on developing and validating targeted assays (proteomics, lipidomics, metabolomics) and ensuring high-quality delivery for clinical trial studies. This role combines hands-on scientific leadership in mass spectrometry, operational project delivery, quality/compliance awareness, and direct collaboration with external study teams.
Key responsibilities
* Lead client projects within the Core Labs programme and drive end-to-end scientific delivery.
* Validate targeted proteomic, lipidomic, and metabolomic assays to appropriate clinical standards (e.g., GCLP, CLIA).
* Design and execute complex experiments; analyse, interpret, and report data under limited supervision.
* Deliver biomarker study outputs for clinical trials in line with scope of work and sponsor timelines.
* Manage day-to-day operational activities across clinical biomarker projects.
* Support preparation and adherence to trial documentation (e.g., project protocols, data transmittal forms).
* Ensure project documentation is complete, current, and stored appropriately.
* Own and maintain key project processes and plans (e.g., project management, communication, escalation, risk plans) and keep records within relevant CTMS.
* Identify scope changes and work with internal teams to update work orders as requirements evolve.
* Prepare metrics and reporting for clients and senior stakeholders.
* Support pre-sales activity alongside commercial leadership by contributing to methodologies, procedures, and analytical pipelines.
* Create and contribute to SOPs for both the overall service and individual projects.
* Engage directly with customers and liaise with external study teams to ensure smooth delivery, including attending progress meetings when required.
* Travel (domestic and international) may be required.
* Undertake other duties aligned to the role, as requested by the line manager.
Skills and experience
* Degree in a relevant biomedical discipline (essential); PhD in biochemistry or related subject (desirable).
* 3+ years’ experience in mass spectrometry operation and method development (essential).
* Experience using Waters triple quadrupole instrumentation (essential).
* Demonstrated experience in mass spectrometry data analysis and assay development (essential).
* Research or clinical lab experience handling human samples (essential).
* Clinical laboratory experience and/or experience developing analytical assays (desirable).
* Quality/compliance exposure within clinical trials settings and/or clinical mass spectrometry (desirable).
* Excellent written and spoken English (essential).
* Strong organisational skills and attention to detail (essential).
* Ability to analyse, interpret, and clearly write up data (essential).
* Strong communication and interpersonal skills (essential).
* Strong IT skills (Word, Excel, Access, PowerPoint) (essential).
* Proven ability to troubleshoot equipment issues and maintain accurate records (essential).
Personal attributes
* Strong commitment to translational research, with sound judgement and the confidence to escalate when needed (essential).
* Proactive, adaptable, and willing to learn new techniques (essential).
* Collaborative team player who can also work independently and deliver effectively (essential).