Overview
We are seeking a Research Assistant to join the Laboratory of Molecular Neurodegeneration in the Department of Physiology, Anatomy and Genetics, University of Oxford. The ideal candidate will be a highly motivated cell biologist with experience in stem cell culture, neuronal differentiation, and phenotypic assays. Strong skills in neurobiology, cell imaging, and molecular techniques are essential, along with the ability to work collaboratively. In this role, you will be responsible for undertaking a range of cell culture activity working with patient primary fibroblasts, iPSC lines and iPSC-derived neurons and glia, performing analysis of Parkinson's molecular and cellular biology and correlating read-outs of cell and molecular biology with detailed clinical phenotypes to contribute to our understanding of Parkinson's disease. This post is funded by the Oxford/GSK Institute of Cellular & Computational Medicine (IMCM) and available immediately until September 2027.
Responsibilities
* Undertake maintenance culture of fibroblast and iPSC lines, and differentiation of iPSC lines into dopamine neurons and glia
* Apply cellular, molecular and imaging assay techniques in iPSC-derived neurons and glia from patients to test cell biology and organelle function
* Contribute to wider project planning, including ideas for new research projects
* Determine the most appropriate methodologies to test hypotheses, and identify suitable alternatives if technical problems arise
* Select, follow, and adapt experimental protocols
* Gather, analyse, and present scientific data from a variety of sources
* Contribute to scientific reports and journal articles and the presentation of data/papers at conferences
* Manage own research and administrative activities, within guidelines provided by senior colleagues
* Collaborate effectively with other team members to achieve collective goals
* Hold or be near to completion of a BSc or MSc degree in neuroscience or cell/molecular biology or equivalent
* Have experience in neuronal/glial cell culture, preferably in human pluripotent stem cells
* Have experience in setting up cellular assays, including image-based experiments
* Have knowledge of neurodegenerative diseases, such as Parkinson's
* Be highly motivated, with the capacity to think creatively and work across teams
* Show commitment to engaging with, and promoting awareness of, equality, diversity and inclusion and embedding these into your work
About the department
At the Department of Physiology Anatomy & Genetics (DPAG) we undertake discovery science where we reassemble physiological processes at the molecular, cellular, tissue and systems level of organisation. In so doing we provide a bridge to translational medicine, and interface between physical and life sciences. We are committed not only to innovative research and the highest standard of teaching, but also to creating an inclusive and supportive working environment.
Benefits
* An excellent contributory pension scheme
* 38 days annual leave
* A comprehensive range of childcare services
* Family leave schemes
* Cycle and electric car loan schemes
* Employee Assistance Programme
* Membership to a variety of social and sports clubs
* Discounted bus travel and Season Ticket travel loans
Your wellbeing at work matters, so we offer a range of family friendly and financial benefits including:
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