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CMC Consultant - LNP Delivery Systems, portsmouth, hampshire
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Client:
Advanced Resource Managers
Location:
portsmouth, hampshire, United Kingdom
Job Category:
Other
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EU work permit required:
Yes
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Job Views:
4
Posted:
31.05.2025
Expiry Date:
15.07.2025
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Job Description:
We are seeking a highly experienced CMC Consultant to support our client, a specialist life science consultancy, in the development of Lipid Nanoparticle (LNP) delivery systems for mRNA-based therapeutics. This consultant will play a key role in identifying and managing CDMO partners, guiding formulation and manufacturing strategy, and supporting mRNA experts with integration into LNP platforms.
This is a project-based, ad-hoc contract role, ideal for a specialist with deep technical expertise in LNP systems and strong knowledge of CMC requirements for mRNA-based drug products.
Responsibilities
CDMO Identification & Oversight
* Assist the client in identifying, evaluating, and selecting CDMOs for LNP development and production.
* Define and assess technical capabilities of CDMOs in:
-Endotoxin testing
-Structure-function assessments (e.g., Zeta potential, particle size, polydispersity, etc.)
* Oversee and support CDMO relationships throughout development lifecycle.
CMC & Formulation Support
* Provide CMC input and strategic guidance on formulation development and manufacturing processes for LNP systems.
* Advise on chemistry, formulation stability, and process scalability of LNP platforms.
mRNA Integration Support
* Work closely with mRNA subject matter experts to:
-Guide loading and encapsulation strategies
-Optimise stabilisation of mRNA within LNPs
-Ensure integrity and efficiency of delivery
Requirements
* Advanced degree (PhD or MSc preferred) in Pharmaceutical Sciences, Chemistry, Biochemistry, or related field
* Extensive experience with LNP delivery systems, ideally in an mRNA therapeutic or vaccine setting
* Proven track record of CMC leadership in formulation, development, and external manufacturing
* Hands-on knowledge of critical LNP attributes such as encapsulation, zeta potential, endotoxin levels, and particle characterisation
* Experience managing or liaising with CDMOs or external partners
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