PhD Studentship: The Structure and Function of the Genome
Supervisor: Professor Sir Shankar Balasubramanian
Department/Location: Cancer Research UK Cambridge Institute
Deadline for application: 13 November 2025
Course start date: 1 October 2026
Overview
Professor Sir Shankar Balasubramanian is seeking a PhD student to work on the structure and function of the genome. The position is based in the Balasubramanian Lab at the CRUK Cambridge Institute, with collaborative interactions with the Yusuf Hamied Department of Chemistry. The research focuses on genomics, computational biology and imaging, with interests in cancers such as breast, pancreas, brain, and colon. The Institute aims to expand the use of AI to generate research hypotheses and explore cancer biology. The Core Facilities provide access to state-of-the-art equipment, in-house expertise and training.
Project details
The student will join a team exploring the formation, dynamics and functions of four-stranded DNA G-quadruplex structures and modified DNA bases in the genome. The research includes mechanisms that regulate gene expression, DNA replication and genome stability, and how these affect cell state changes. The project emphasizes novel methods to investigate genome function, including mapping binding of nucleic acid-interacting drugs and small molecules, and genome sequencing of modified bases in relation to chromatin proteins.
Selected publications related to the group’s work include Genome Biology (2021, 2025), Nature Chemistry (2025), PNAS (2024, 2025), Nature Biotechnology (2023, 2023), and related venues.
Preferred skills/knowledge
* Strong motivation and ability to work independently and in collaboration
* Background in molecular biology and/or biochemistry
* Good knowledge of genomics and nucleic acid chemistry/chemical biology is highly desirable
Funding and duration
This is a four-year studentship funded by Cancer Research UK Cambridge Institute. It covers university fees and includes an index-linked stipend starting at £22,500 per year.
Eligibility
* Open to UK and overseas applicants
* Applications are invited from recent graduates or final-year undergraduates with a First or Upper Second Class degree (or equivalent) in a relevant subject
* Applicants with relevant research experience (Masters or laboratory work) are strongly encouraged to apply
How to apply
Apply via the University Applicant Portal. For course information and to access the Applicant Portal, visit: https://www.postgraduate.study.cam.ac.uk/courses/directory/cvcrpdmsc
You should select to commence study in Michaelmas Term (October) 2026. Include the project name and supervisor reference where indicated. You may apply for up to three projects.
Application components
* Research Experience (up to 2,500 characters)
* Statement of Interest (up to 2,500 characters) explaining motivation and relevant experience
* Academic transcripts
* Evidence of English competence (if applicable)
* Details of two academic referees
* CV/resume
Deadline and interview
Closing date: Thursday 13 November 2025. Interviews will take place on Tuesday 25 November 2025.
The University is committed to equality, diversity and inclusion and encourages applications from all sections of society. The University also has a responsibility to ensure that all employees are eligible to live and work in the UK.
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