Senior Clinical Research Associate – England
Chloe O'Shea is proud to partner with a leading global CRO renowned for delivering innovative, high-quality solutions in clinical development. We are seeking an experienced Senior Clinical Research Associate (Senior CRA) to join a dedicated single-sponsor team in England. This is an exciting opportunity to work on cutting-edge studies, with a particular focus on advanced therapy areas such as CAR-T and gene therapy. While prior experience in these fields is highly valued, it is not essential - full training and support will be provided.
The Role
As a Senior CRA, you will be a key contributor to the successful delivery of clinical trials across England. You will oversee site management activities, act as a primary liaison with investigative sites, and ensure strict compliance with protocols, ICH-GCP, and UK regulatory requirements (MHRA/REC). This role is well-suited to ambitious CRAs ready to step up or established Senior CRAs seeking to deepen their expertise in innovative therapy areas.
Key Responsibilities
* Independently manage qualification, initiation, monitoring, and close-out visits across England.
* Ensure high standards of compliance with ICH-GCP, MHRA, REC requirements, and sponsor SOPs.
* Perform source data verification, investigational product accountability, and ensure accurate site documentation.
* Serve as a trusted partner to site personnel, offering training, guidance, and ongoing support.
* Identify site-level challenges proactively and drive timely resolution.
* Contribute to mentorship of junior CRAs and share best practices within the monitoring team.
* Maintain complete and accurate trial documentation in CTMS, eTMF, and EDC systems.
Requirements
* Bachelor's degree in Life Sciences, Nursing, Pharmacy, or a related discipline.
* Minimum 3 years of independent UK monitoring experience, ideally with exposure to complex studies.
* Experience in
CAR-T and/or gene therapy
is highly desirable but not required.
* Strong knowledge of ICH-GCP and UK clinical trial regulations (MHRA/REC).
* Excellent communication, relationship-building, and organisational skills.
What's in It for You?
This role offers a
competitive salary and benefits package
, flexible working arrangements, and clear opportunities for career progression within one of the world's largest CROs. You'll gain exposure to innovative therapies shaping the future of healthcare, while working in a collaborative culture that values professional development, work-life balance, and wellbeing.
If you are a driven Senior CRA — or an experienced CRA ready to take the next step — we'd love to hear from you. Apply today to join a global team making a meaningful difference in patients' lives.