Associate Scientist I – Permeability and Transporter Team
Are you a new graduate within the Life Science/Pharmacology field, wanting to contribute to global drug discovery? If so, then this could be the opportunity for you
Role: Associate Scientist I– Permeability and Transporter Team
Role Type: 12 month fixed term contract
Direct Report: to Senior Scientist – Permeability and Transporter Team
Hours: Full time, 37.5 hours per week
Salary: £26 000 pa, dependant on skills and experience, excellent benefits package plus annual bonuses
Location: , Macclesfield, SK10 4TG.
Our Company
Cyprotex vision is to be pioneers of innovative ADME-Tox partnerships, driving delivery of safer and more effective medicines. With state-of-the-art facilities and technical expertise, we specialise in in vitro and in silico ADME-Tox services, providing a wide range of assays tailored to our client's needs. This includes in vitro screening to support discovery projects, regulatory studies to support preclinical and clinical development, specialist mechanistic in vitro human and animal toxicity models and PBPK/QSAR modelling expertise. As well as supporting clients directly, we have a strong focus on R&D.
Our Alderley Park site is set in the heart of Cheshire surrounded by stunning 400-acre estate, open green spaces, sweeping viewpoints, all within easy reach of Merseyside and Greater Manchester, Staffordshire, and Shropshire. Easy access to public transport.
An exciting opportunity has arisen to join our team of drug permeability and transporter scientists. We are responsible for delivering high quality permeability, transporter substrate, and transporter inhibition data to our clients, supporting projects from early discovery right through to clinical development. As a member of our team you will develop in depth technical expertise across all these areas and understand how this data is utilised to support drug discovery and inform clinical development.
Role
As an Associate Scientist you will be working within our Permeability & Transporters team dedicated to delivering high quality in vitro permeability screening (in MDCK-MDR1 or Caco-2 polarised cell monolayers) and drug transporter profiling (substrate and inhibition assessment) data to clients in order to assist them in understanding the absorption and drug-drug interaction properties of their molecule, towards driving its preclinical and clinical development. Indeed, the findings of the in vitro transporter profiling studies you perform at the bench link to patient safety at the bedside and are often included in the patient leaflet (drug label) for a new medicine in the drug interactions section.
Associate Scientists work closely with more experienced laboratory staff (Scientists) on all aspects of permeability screening or transporter profiling studies from the routine cell culture of transfected cell test systems and conduct of experiments, through to data processing and reporting.
Key Responsibilities
* Support the execution of routine and bespoke permeability screening and uptake/efflux transporter assays (both manually and using liquid-handling robots), and processing data to a high quality, within specified timelines
* Assist in data analysis/interpretation by applying scientific knowledge
* Assist in running and maintaining liquid-handling robots to support high throughput ADME-TOX processes
* Support later-stage substrate identification and inhibition studies for a range of uptake and efflux transporters
* Perform cell culture using aseptic techniques
* Follow safety regulations and quality control procedures
* Prepare, monitor and maintain compounds, stock solutions and buffers and be responsible for the validation and routine maintenance of laboratory equipment
Education, Qualifications and Experience
* MSc or BSc degree or equivalent or significant & previous direct industrial laboratory experience
* Previous experience of working within a laboratory environment and/or direct experience of in vitro permeability and/or transporter assays and cell culture techniques would be advantageous
* Experience of general laboratory processes and/or liquid handling robotics (such as Tecan EVO platform) would be advantageous
* Able to exchange and understand key information with team members using a variety of communication tolls
* Able to organise daily tasks, to ensure delivery within agreed deadlines
Company Benefits
We offer a competitive salary and benefits package
* Pension on completion (but not subject to) of your 3-month probationary period. Contributions 5% for employees (salary sacrifice) and 5% for the employer. The employee can opt to increase their contribution and the employer will match the increase up to a maximum of 7.5%
* 25 days holiday plus bank holidays and additional length of service days awarded on the anniversary, up to a maximum of 30 days
* Private health insurance with BUPA for the employee and their partner/family under the company scheme
* Well being support 24/7 and counselling services
* Permanent health insurance providing 75% of base salary after the qualifying period
* Private dental cover, on completion (but not subject to) of your 3-month probationary period
* Eligibility to participate in the Company Bonus Scheme. This is a discretionary benefit.
* Career progression within the company, we have an excellent training and support and continuing professional development opportunities
* Cycle to work scheme
* Refer a friend scheme, team and annual events, recognition awards and many more
Onsite Facilities
* Company pays for secure onsite parking
* Café and a Gastro pub
* Gym and workout studio, running, walking, and cycling routes
* Good public transport links with the shuttle bus service
Interested?
Apply NOW – please upload your up-to-date CV and covering letter to Workday via our careers page. Click the link
Job Types: Full-time, Permanent
Pay: Up to £26,000.00 per year
Work Location: In person