About us
We are looking for a talented PhD student to join the Molecular Biology of Cancer Laboratory, led by Dr. Ivana Bjedov, at the UCL Cancer Institute (Bjedov Lab | Molecular Biology of Cancer | UCL Cancer Institute). The project is collaborative with Prof. Susana Godinho (Queen Mary University of London).
The Bjedov lab focuses on ageing and cancer, with emphasis on protein synthesis, DNA repair, and ageing research to protect normal tissues from radiation therapy side effects. The Godinho lab specializes in centrosome biology and tumorigenesis and employs model systems including 2D and 3D cell cultures.
About the role
Project Overview
Radiotherapy is a cornerstone of cancer treatment, yet effective radioprotectors remain elusive. This PhD project explores how protein synthesis influences radiation response in cancer and normal tissues. By understanding translational changes post-radiation, we aim to identify novel targets to enhance radiotherapy outcomes.
Research Aims
* Aim 1: Use patient-derived assembloids to monitor macromolecular damage and protein synthesis after radiation exposure.
* Aim 2: Characterise differential translation in tumour vs. fibroblast cells using ribosome profiling and RNA-seq.
* Aim 3: Validate top candidate genes/pathways via pharmacological and CRISPR/Cas9 approaches to modulate radiation response.
Training & Environment
You will join a collaborative, multidisciplinary team at the UCL Cancer Institute, gaining hands-on experience with cutting-edge models (assembloids, organoids) and technologies. The project bridges cancer biology and ageing research, offering a unique opportunity to contribute to translational science with real clinical impact.
About you
Eligibility:
Applicants must hold (or expect to obtain) a First or Upper Second Class Honours degree in a relevant biological science. Experience in molecular biology and a strong interest in cancer research are essential.
Deadline and Application Process
p>The deadline for submission is: noon November 5th 2025
First round of interviews and selection will be online or in person in late November or early December. Second round of interviews is scheduled for 12 January 2026.
Application key dates
* Your application must be submitted by the deadline: 5 November 2025, noon
* We should receive your references by 12 November 2025, noon. Your application may still be considered if references are not received by this deadline. However, no applicant will be invited to interview unless references have been received.
* You will find out if you have been invited to interview for the programme before: 5 January 2026
* Information session for interviewees: 6 January 2026, noon
* Panel interviews will take place: w/c 12 January 2026
* Programme start date: September 2026
How to apply
p>For full details and to apply please use the link or contact i.bjedov@ucl.ac.uk.
What we offer
p>Funding and Duration: Fully funded by CRUK for 4 years (full-time)
Successful candidates will receive a non-taxable annual stipend of £23,000 per annum (current CRUK London rate). Tuition fees for Home status only. For more information on Home tuition fee status please visit the UKCISA website.
Equality, Diversity and Inclusion
As London\'s Global University, we know diversity fosters creativity and innovation, and we want our community to reflect the world\'s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are underrepresented in UCL\'s workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women.
Our department holds an Athena SWAN Gold award in recognition of our commitment and impact in advancing gender equality.
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