Applications are invited for a Research Assistant to join the group of Dr Alexander Frankell within the Early Cancer Institute on the Cambridge Biomedical Campus. This is an exciting opportunity to join a methods development programme, funded by the Wellcome Trust which aims to develop novel approaches to extract critical biological signals from non-invasively collected samples from individuals diagnosed with or at risk of cancer, for example using circulating tumour DNA in blood plasma. In particular, we are focused on tracking signals of chromosomal Instability and cancer heterogeneity which are critical to the development, progression and treatment resistance of many malignancies. Our methods aim to provide insights into how cancers evolve via longitudinal tracking but also to underpin future cancer biomarkers for detection and risk stratification. Our lab has a background studying malignant development in the oesophagus and lung alongside our collaborators in the TRACERx, OCCAMS and BEST4 studies with whom we work closely (Prof. Charles Swanton, Prof Rebecca Fitzgerald and others). We are inviting applications from motivated individuals a with a strong interest in NGS and diagnostics. During the post there will be opportunities to learn and optimise novel NGS workflows for high depth sequencing with error suppression involving duplex sequencing and, additionally, to develop and/or extend computational skills if desired by the candidate. The successful candidate will also have responsibilities to aid management and efficiency of the laboratory as a whole alongside Dr Frankell. Applicants must have a degree in a related field and working experience in relevant experimental procedures, for example DNA extraction, library preparation and cell culture. The ideal candidate will have strong experience in library preparation for NGS and molecular barcoding for deep sequencing. The role holder must also have excellent communication skills with a proven track record of interacting effectively within interdisciplinary teams (biologists, medics, computer scientists, etc), and a willingness to become familiar with the somatic evolution field. Prospective candidates are encouraged to contact Alexander Frankell (amf71@cam.ac.uk) directly when considering an application to discuss the project in greater detail. Fixed-term: The funds for this post are available for 2 years in the first instance. Closing date: 10th November 2025 Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online. Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager. Please quote reference RD47639 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK. Apply online