We are partnered with an immuno-oncology focused biotech in Oxford seeking to hire a Senior Scientist with expertise in Cancer Biology. This role requires a PhD in a relevant field. Prior industry experience is highly desirable and familiarity with bioinformatics is a plus.
Responsibilities
* Contribute to a collaborative, high-integrity biotech research environment with strong standards for documentation, reproducibility, and compliance
* Support and help shape translational research strategy across early-stage discovery programmes in collaboration with a small multidisciplinary team
* Design, execute, and optimise in vitro experimental systems including 2D and organoid-based models
* Develop and refine assays for evaluating cell viability, cytotoxicity, and molecular readouts including sequencing-based methods
* Troubleshoot technical and scientific challenges to ensure high-quality, decision-enabling data generation
* Analyse, interpret, and present experimental results to guide project direction and progression
* Maintain compliance with internal SOPs and regulatory requirements, including mandatory training
Requirements
* Extensive experience handling human epithelial and cancer cells
* Experience in culture and expansion of primary epithelial cells
* Strong expertise in genetic manipulation of epithelial and cancer cells
* Experience developing cellular assays for viability, proliferation, and cytotoxicity studies
* Ability to design and perform qPCR, ELISA, and flow cytometry experiments
* Experience in immunofluorescence staining and microscopy
* Experience growing primary cancer cells in culture
* Experience developing and maintaining organoid models is highly desirable
* Prior experience with real-time imaging systems (e.g. Incucyte) and familiarity with RNA/DNA sequencing