Join to apply for the Separation Scientist (Purification) / NMR Technician role at Sygnature Discovery
Join to apply for the Separation Scientist (Purification) / NMR Technician role at Sygnature Discovery
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Background
Sygnature Discovery is a world-leading integrated drug discovery Contract Research Organisation based in the UK and Canada with its headquarters in Nottingham and additional facilities in Alderley Park, Macclesfield, Glasgow, Montreal and Quebec City. Its staff of over 1,000, which includes 900 scientists, partners with global pharma, biotech and NFP organisations.
Background
Sygnature Discovery is a world-leading integrated drug discovery Contract Research Organisation based in the UK and Canada with its headquarters in Nottingham and additional facilities in Alderley Park, Macclesfield, Glasgow, Montreal and Quebec City. Its staff of over 1,000, which includes 900 scientists, partners with global pharma, biotech and NFP organisations.
Since 2004, Sygnature Discovery has delivered over 56 novel pre-clinical and 35 clinical compounds, with its scientists named on over 225 patents. Therapeutic areas of expertise include oncology, inflammation and immunology, neuroscience, metabolic diseases, infectious diseases, and more. To find out more, please visit www.sygnaturediscovery.com.
About the role:
If you are interested in accelerating your career in chromatography and working with state-of-the-art technology and instrumentation, then a role in Separation Science is for you.
Analytical Scientists at Sygnature Discovery play an essential role in supporting integrated client projects as well as delivering specialist services. The growing team is looking for talented scientists to push our capabilities even further.
Your main role as a Separation Scientist (90%) will be to develop new chromatographic methods and to undertake purification by preparative HPLC alongside maintenance of both analytical and preparative instrumentation.
A secondary aspect of the role (10%) will be to maintain our NMR spectrometer. You will work alongside the NMR team to manage its upkeep and ensuring its availability for our Chemistry teams.
Role Responsibilities:
* Solve chromatographic problems on a wide and diverse chemical space using state-of-the-art instrumentation.
* Carry out semi-automated purification process on milligram to gram scale as well as developing bespoke analytical and preparative methods.
* Undertake preparative and analytical HPLC and LCMS on a daily basis and to troubleshoot instrument problems.
* Provide achiral purification support to medicinal chemistry project teams and comply with departmental KPIs.
* Develop high-throughput purification workflows.
* Maintain an NMR spectrometer for walkup use by chemists, ensuring upkeep and performing weekly cryogen fills.
* Integrate and learn from industry leading chromatographic and NMR groups.
* Propose and implement new initiatives to improve workflow efficiency and enhance chromatographic capabilities.
Skills & Qualifications:
* BSc/MSc in Chemistry (or related subject) with core drug discovery and purification experience.
* Experienced in chromatographic data analysis and interpretation.
* Hands on experience of developing preparative chromatography methods using a range of techniques.
* Hands on experience in applying these methods to the isolation and purification of small molecules over a range of scales.
* Knowledge and experience of state-of-the-art preparative and analytical instrumentation with the ability to identify and troubleshoot equipment issues.
* Understand the influence of structural characteristics / chemistry of compounds on chromatographic behaviour.
* Practical experience in the operation of NMR spectrometers is desirable.
* Ability to multitask across different workflows (Chromatography and NMR) and efficiently prioritise key tasks and requests.
* Self-motivated and capable of working independently, with a flexible approach and excellent problem-solving skills.
* Possess a collaborative mindset and the ability to communicate in a scientific manner with attention to detail.
If you have any questions or need further information, please contact the Talent Acquisition team at careers@sygnaturediscovery.com. Please do not submit your application to this email address.
Benefits
* 25 days annual leave (plus bank holidays)
* Private Medical Insurance
* ️ Life Insurance
* Employee Assistance Programme
* ️ Enhanced Family Friendly Policies
* Sygnature Group Pension Scheme
* 1 paid volunteer day per year
Seniority level
* Seniority level
Entry level
Employment type
* Employment type
Full-time
Job function
* Job function
Research, Analyst, and Information Technology
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