As Principal Scientist in the Translational Unit within RII RU, you will play a critical role in bridging preclinical target and asset validation and early clinical proof of concept studies by designing and performing translational assays in human-derived cells, tissues, biofluids, and surgical discard organs.
Despite the listing of GSK-Upper Providence as the primary job location, candidates will be considered equally from the Upper Providence, Pennsylvania (USA) and Stevenage (UK) sites. This is a lab-based position with an anticipated 4-5 days on-site presence in the laboratory.
1. Design, execute, and analyze laboratory experiments to advance scientific understanding and support drug discovery.
2. Apply hands-on expertise in several of the following capabilities: ELISA/MSD/Quanterix, Western/JESS, flow cytometry, gene expression analysis, extracellular vesicle isolation, iPSC cell culture, and emerging technologies.
3. Present findings to internal teams, stakeholders, and governance in a balanced, clear, and precise manner.
4. Maintain accurate and detailed laboratory records in alignment with data integrity expectations and ensure compliance with all relevant protocols and safety guidelines.
5. Effectively trouble-shoot assays and, when necessary, develop alternative approaches.
6. Work closely with preclinical statistics and other relevant teams to ensure robust study design of experiments.
7. Work closely with other RII RU lines such as the Biology Unit and Clinical to design, optimize, and execute preclinical studies to strengthen target-disease hypotheses and provide evidence for GSK translational pillars by using human ex vivo samples.
8. Provide technical and disease input into the translational strategy for one or more projects and influence project direction through interpretation and integration of relevant project and other data.
9. Utilize a growing internal and external network to build translational expertise in technology and disease areas; act as a go to expert on specific technologies and/or disease mechanisms in neurodegeneration, renal disease, or liver disease.
10. Identify and progress collaborations with external partners, including academic institutions and contract research organizations, to leverage expertise and resources to support translational studies.
11. Stay up to date with the latest scientific literature and emerging technologies relevant to translational research.
12. Ensure compliance with all applicable laws, regulations, and ethical standards in the conduct of translational research.
13. Foster a culture of innovation, collaboration, and continuous learning within the translational research team and across the organization.
Basic Qualifications:
14. PhD in a scientific discipline (e.g., Molecular Biology, Genetics, Immunology, or related field).
15. 4+ years’ experience in translational and biomarker development.
16. Disease area expertise in neurodegeneration, renal disease, or liver disease.
17. Experience in several of the following technical capabilities: bioassay development and analysis (ELISA/MSD/Quanterix), flow cytometry, DNA and RNA sequencing technologies, extracellular vesicle isolation, iPSC cell culture, and emerging technologies.
18. Experience in human systems using cell and molecular biology, bioassays, and analytic methods.
19. Experience with scientific innovation as evidenced by effective support of drug discovery projects, peer-reviewed publications, conferences, internal reports, technical evidence documents or patents.
Preferred Qualifications:
20. Familiarity with bioinformatics tools for the interpretation of large-scale datasets.
21. Excellent problem-solving skills and ability to critically analyze scientific data.
22. Strong written and verbal communication skills, with the ability to effectively present scientific findings to multidisciplinary internal and external stakeholders in a balanced, clear, and precise manner.
23. Proven ability to balance priorities across multiple objectives, meeting timelines while maintaining attention to detail and high-performance standards.
24. Able to independently define strategic approach to tackle specific project or department goals.
25. Ability to work independently as well as collaboratively in a team-oriented environment.
26. Resourcefulness to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities.
27. Experience in the design and execution of biomarker-driven clinical trials and the development of companion diagnostics.
28. Knowledge of regulatory guidelines and compliance requirements related to translational research and clinical development.
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GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
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