Under the guidance of Professor Trevor Graham, we are seeking to recruit a Postdoctoral Training Fellow to perform molecular genomics and single cell sequencing studies of cancer evolution. The successful candidate will play a key role to undertake research into the evolutionary dynamics that underpin colorectal cancer development and response to treatment. The post holder will perform experimental lab work to generate molecular genomics data, particularly single cell data, from patient material, cell lines, organoids and other sample types.
About you
The successful candidate must have:
1. PhD in molecular biology or other relevant area
2. Ability to perform advanced NGS experiments for the analysis of cancer genomes
3. Proven expertise in advanced NGS technologies, including RNA-seq, DNA-seq, and single-cell sequencing.
4. Ability to prepare scientific reports and present data at regular project meetings.
Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment.
The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years.
For general information on Postdocs at The ICR, more information can be found here.
Department/Directorate Information
The Centre for Evolution and Cancer (CEC), within the Division of Cancer Biology, is a multidisciplinary centre, comprising around 50 staff dedicated to understanding cancer evolution and leveraging this knowledge for translational benefit. Our interests span early detection through to treatment of metastatic disease. The CEC brings together expertise in evolutionary theory, computational biology and bioinformatics together with cutting-edge research ability in cell and molecular biology to provide a stimulating and creative interdisciplinary environment where new approaches to tackling cancer can thrive.
The Genomics and Evolutionary Dynamics team combine molecular and cellular biology together with mathematical and computational modelling to study the evolution of malignancy. We focus on early detection in the gastrointestinal tract, colorectal cancer evolution and treatment response, and pan-cancer genomics. We perform basic research into the biology of the human body in health and disease and translate our findings to improve clinical care of patients affected by cancer.
We are based at the ICR Sutton site within the Centre for Evolution and Cancer, located in the outstanding facilities of the new Centre for Cancer Drug Discovery building. The team is highly experienced computational biology and mathematical modelling that is closely coupled to biological and clinical data. We are leaders in multi-omic data generation and integration, and using this in-house data together with large publicly available datasets, we apply the principles of evolutionary biology and ecology to understand the natural history of cancer. Pertinent to this role, we are equipped with cutting-edge single cell sequencing technologies such as the cellenONE (Cellenion) and the Chromium system (10X Genomics), a CODEX platform (Akoya Bioscience) for highly multiplexed spatial analysis, and have on-site world-class sequencing facilities.
What we offer
5. A dynamic and supportive research environment
6. Access to state-of-the-art facilities and professional development opportunities
7. Collaboration with leading researchers in the field
8. Competitive salary and pension