15th May, 2026 Principal Analytical Chemist SE England Permanent Our SE based client is currently looking to recruit a Principal Analytical Chemist to perform complex method development and validation using LC-MS / HPLC on a variety of synthesised chemicals and API molecules. This is a hands-on role and would suit someone who enjoys developing novel methods from first principles in busy commercial manufacturing environment. Additional duties for this role will include : Leading a small team of Analytical Chemists, assisting with ongoing project work when required Instrument and method trouble-shooting, solving problems to enable analyses to be completed Working with Synthetic / Process Chemists to understand synthesised chemicals to ultimately ensure the successful analysis of a range of molecules Leading on a number of analytical projects, understanding GMP requirements and defining scope of analytical projects and milestones Understanding / performing analyses with a range of other chromatography, spectroscopy and techniques (including NMR, ICP and others) Completing detailed GMP documentation and reports, ensuring analytical success Understanding new approaches in analytical methodologies and techniques and implementing method improvements Training and mentoring others, leading by example on complex problem solving challenges Applications are invited from candidates with a BSc, MSc, PhD in Analytical Chemistry (or similar) together with proven demonstrable hands-on skills performing complex GMP method development and validation using chromatography systems in an API / synthesis environment For further information or to apply please contact martin@entrustrs.com 01606 818294 This is a permanent role offering an attractive salary depending on skills and experience Role : Permanent Location : SE England