Orion Group Sciences is seeking a Principal Scientist to direct and inform our client's process development and discovery. The ideal candidate will have a deep understanding of protein expression systems and how to optimise conditions to improve protein quality. They will also require a good knowledge of protein purification methods to leverage the optimisation in expression conditions to maximise final protein quality. This two-year contract offers the opportunity for the successful candidate to join a dynamic team that works across multidisciplinary functions in a leading AgriTech business.
Role profile:
Lead upstream process development for recombinant protein production.
Provide scientific leadership and technical guidance to team members and project teams.
Be the technical lead to translate expression optimisation from shake flask to bioreactor.
Design and refine expression methods and protocols to optimize protein quality.
Investigate the relationship between expression conditions and protein quality attributes across key projects.
Collaborate with team members and across functions to enhance overall process improvements.
Drive optimisations in upstream processes with a data led approach.
Work safely and with due care to others ensuring compliance with company HSE policies.
Essential experience:
Post Doc or equivalent experience in Biotechnology, Microbiology or other similar disciplines.
8 + years of hands-on experience in upstream bioprocessing with expertise in:
Recombinant protein expression (bacterial, insect, yeast or plant systems).
Knowledge and experience of working with bioreactors.
Experience and knowledge of transferring shake flask processes into bioreactors.
Good knowledge of protein purification methods and techniques.
Strong evidence of troubleshooting and innovative problem solving.
Strong understanding of how upstream decisions impact downstream processing outcomes.
Excellent communication skills with the ability to present complex concepts clearly.Desirable experience:
Knowledge of how construct design can impact protein expression.
Knowledge and application of AI tools and models to inform experimental design.
Knowledge of DoE approaches for method optimisation.
Experience with Ambr250 micro bioreactor systems.
Background in protein characterisation to validate protein quality from a bioprocess.
Experience of working with scalable bioprocess technologies e.g. Tangential flow filtration (TFF)
Industry experience in Biopharma, AgriTech or related sectors.
Our role in supporting diversity and inclusion
As an international workforce business, we are committed to sourcing personnel that reflects the diversity and values of our client base but also that of Orion Group. We welcome the wide range of experiences and viewpoints that potential workers bring to our business and our clients, including those based on nationality, gender, culture, educational and professional backgrounds, race, ethnicity, sexual orientation, gender identity and expression, disability, and age differences, job classification and religion. In our inclusive workplace, regardless of your employment status as staff or contract, everyone is assured the right of equitable, fair and respectful treatment